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GF300 Sigma-Aldrich

Activin A Protein, Human Recombinant Animal Free

Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins purified from gonadal fluids as proteins that stimulated pituitary follicle stimulating hormone (FSH) release.

Synonym: Inhibin, Activin-A, Erythroid differentiation protein

  •  eCl@ss 32160405

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Properties

Quality Level   100
assay   >97% (SDS-PAGE and HPLC)
mfr. no.   Chemicon®
impurities   <0.1 μg/mg protein endotoxin (<1EU/μg)
UniProt accession no.   P08476
shipped in   dry ice

Description

General description

Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purified from gonadal fluids as proteins that stimulated pituitary follicle stimulating hormone (FSH) release. Activin proteins have a wide range of biological activities, including mesoderm induction, neural cell differentiation, bone remodeling, hematopoiesis and roles in reproductive physiology. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, follistatin. Recombinant human Activin A is a 26.0 kDa disulfide-linked homodimer of two βA chains, each containing 116 amino acid residues.

Product Source: E. coli

Specificity

Cross Reactivty
Chicken, Dog, Frog, Mouse, Human and Mouse

Application

Research Category
Stem Cell Research

Research Sub Category
Growth Factors & Receptors

Quality

Bioactivity assay: determined by its ability to inhibit the proliferation of mouse MPC-11 cells. The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.

Physical form

Product is filtered through a 0.2 micron filter before lyophilization.

Recombinant animal free human Activin A is manufactured using all non-animal reagents

Storage and Stability

Store at -20°C for up to 6 months from date of receipt.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety & Documentation

Safety Information

Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
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