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GF304 Sigma-Aldrich

GM-CSF Protein, Human Recombinant Animal Free

The GM-CSF protein was initially characterized as a factor that can support the in vitro colony formation of granulocyte macrophage progenitors. The Recombinant animal free human GM-CSF is manufactured using all non-animal reagents.

Synonym: GMCSF, M-CSF, CSF-1, Granulocyte Colony Stimulating Factor, Macrophage Colony Stimulating Factor, Granulocyte/Macrophage Colony Stimulating Factor, G-CSF

  •  eCl@ss 32160405

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Properties

Quality Level   100
assay   >98% (SDS-PAGE and HPLC)
impurities   <0.1 μg/mg protein endotoxin (<1EU/μg)
NCBI accession no.   NM_000757.3
  NM_172210.1
  NM_172211.1
  NM_172212.1
UniProt accession no.   P09603
shipped in   dry ice

Description

General description

Granulocyte/Macrophage Colony-Stimulating Factor (GM-CSF) was initially characterized as a factor that can support the in vitro colony formation of granulocyte macrophage progenitors. It is also a growth factor for erythroid, megakaryocyte, and eosinophil progenitors. GMCSF is produced by a number of different cell types (including T cells, B cells, macrophages, mast cells, endothelial cells, fibroblasts, and adipocytes) in response to cytokine or inflammatory stimuli. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant human GM-CSF is a 14.6 kDa globular protein consisting of 128 amino acids containing two intramolecular disulfide bonds and two potential N-linked glycosylation sites.

Product Source: E. coli

Specificity

Cross Reactivty
None

Application

Research Category
Inflammation & Immunology

Research Sub Category
Growth Factors & Receptors

Quality

Bioactivity assay: The ED50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.

Physical form

Product is filtered through a 0.2 micron filter before lyophilization.

Recombinant animal free human GM-CSF is manufactured using all non-animal reagents

Storage and Stability

Store at -20°C for up to 6 months from date of receipt.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
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