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IL011 Sigma-Aldrich

Interleukin-11, recombinant

The recombinant Interleukin-11 protein (or IL-11 protein) is a potent lymphoid cell growth factor which stimulates the growth & survivability of certain B-cells & T-cells.

Synonym: IL-11

  •  eCl@ss 32160405

  •  NACRES NA.75

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Properties

biological source   human
application(s)   cell analysis: suitable (cell culture)
shipped in   dry ice
Quality Level   100
assay   >98% (SDS-PAGE and HPLC)
activity   ≥5 x 105 U/mg
mfr. no.   Chemicon®
impurities   <0.1 ng/μg Endotoxin (1EU/μg; IL-11)
input   sample type hematopoietic stem cell(s)
NCBI accession no.   NM_000641.2
UniProt accession no.   P20809
Gene Information   human ... IL11(3589)

Description

General description

Interleukin-11 (IL-11) is a potent lymphoid cell growth factor which stimulates the growth and survivability of certain B-cells and T-cells. Human IL-11 is a 19.1 kDa protein containing 179 amino acid residues.

Application

For most in vitro applications, IL-11 exerts its biological activity in the concentration range of 0.1 to 10.0 ng/mL. Responding cells are (partial list): Certain B-cells and T-cells.

Storage and Stability

The lyophilized powder, though stable for a few weeks at room temperature, is best stored at -20°C. After a quick spin, reconstitute in water to a concentration of 0.5-1.0 mg/mL. Please note: This solution is slow to dissolve. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or -20°C for future use. Reconstituted IL-11 should be stored in undiluted aliquots at -20°C for up to six months.

Biochem/physiol Actions

The ED(50) as determined by the dose-dependent stimulation of the proliferation of mouse T11 cells is ≤ 2 ng/mL

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
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