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AB2290A4 Sigma-Aldrich

Anti-MAP2, Alexa Fluor 488 Conjugate Antibody

This Anti-MAP2, Alexa Fluor 488 Conjugate Antibody is validated for use in ICC, IHC for the detection of MAP2.

Synonym: Microtubule-associated protein 2, MAP-2, MAP2

  •  eCl@ss 32160702

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Properties

Related Categories Antibodies, Primary Antibodies More...
packaging   100 µL (AB2290A4)
format   AlexaFluor®488
molecular weight   The unconjugated parent antibody (Cat. No. AB2290) has an observed molecular weight at ~260 kDa.
application(s)   Immunocytochemistry
  Immunohistochemistry
clone   Polyclonal Antibody
host   Rabbit
species reactivity   Rat
NCBI accession no.   NP_037198
UniProt accession no.   P15146
gene symbol   Map2
  Mtap2
shipped in   wet ice
Quality Assurance   Evaluated by Immunocytochemistry in rat E18 cortex cells.

Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected MAP2 in rat E18 cortex cells.

Description

General description

The microtubule-associated protein 2 (MAP-2) is an abundant neuronal cytoskeletal protein that binds to tubulin, stabilizes microtubules (Herzog and Weber, 1978), and is an excellent marker for neurons. MAP-2 is essential for the development and maintenance of neuronal morphology (Matus, 1991). Three primary isoforms of MAP-2, the high molecular weight MAP2a and MAP2b, and the low molecular weight MAP2c (resulting from alternate splicing of the MAP2 gene), have been identified in neurours. (Chung et al., 1996). The low molecular weight isoform, MAP2c, is expressed in developing brain and is down-regulated during brain maturation, whereas the high molecular weight MAP2b is expressed in both developing and adult brain. The MAP2a appears only after brain maturation (Tucker, 1990). All these forms bind to microtubules through a domain near the carboxyl terminus that contains either three or four similar repeats of a 31-amino-acid motif (Lewis et al., 1988). MAP-2 together with MAP-4 and tau proteins belong to the family of thermostable proteins associated with microtubules.

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Certificate of Analysis

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