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  • AB2959 - Anti-ADAM 9 Antibody, disintegrin domain

AB2959 Sigma-Aldrich

Anti-ADAM 9 Antibody, disintegrin domain

clone, from rabbit

Synonym: ADAM metallopeptidase domain 9 (meltrin gamma), a disintegrin and metalloproteinase domain 9 (meltrin gamma), Cellular disintegrin-related protein, Myeloma cell metalloproteinase, Metalloprotease/disintegrin/cysteine-rich protein 9

  •  eCl@ss 32160702

  •  NACRES NA.41



Related Categories AD-AD, Alphabetical Index, Antibodies, Primary Antibodies
clone   polyclonal
biological source   rabbit
application(s)   western blot: suitable
species reactivity   human, primate, human, chimpanzee
species reactivity (predicted by homology)   chimpanzee (based on 100% sequence homology), primate (based on 100% sequence homology)
shipped in   wet ice
Quality Level   100
antibody product type   primary antibodies
NCBI accession no.   NP_003807
UniProt accession no.   Q13443
Gene Information   human ... ADAM12(8038), ADAM9(8754)


General description

A disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) belongs to a family of transmembrane, membrane-anchored, disintegrin-containing proteins that are involved in several biological functions such as protein ectodomain shedding, cell fusion, and cell adhesion. ADAMs contain several characteristic domains, two of which, the protease and disintegrin domains, are noted for their homology to snake venom metalloprotease. The exact function of ADAM 9 is yet unknown, however it is widely distributed, is found within keratinocytes, and is ideally placed on the cell membrane, which some studies have suggested supports a role in cell migration and motility. Alternative splicing results in two isoforms; isoform 1 is found within the cell membrane and is considered a single-pass type 1 membrane protein, while isoform 2 is secreted. Mutations in ADAM 9 expression are causal to cone-rod dystrophy type 9 or CORD9 which is characterized by visible retinal pigment deposits and loss of cone photoreceptors leading and rod degeneration, ultimately resulting in severe loss of vision.


Mouse and rat (90% sequence homology).


Epitope: disintegrin domain

KLH-conjugated linear peptide corresponding to the disintegrin domain of human ADAM 9.


Detect ADAM 9 using this Anti-ADAM 9 Antibody, disintegrin domain validated for use in WB.

Research Category
Cell Structure

Research Sub Category

Target description

~ 90 kDa observed. 2 isoforms are produced by alternative splicing: Isoform 1 at 91 kDa and Isoform 2 at 72 kDa

Physical form

Format: Purified

Protein A Purfied

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl, with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


Evaluated by Western Blot in human chondrocyte cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected ADAM 9 in 10 µg of human chondrocyte cell lysate.


Replaces: AB19025

Analysis Note

Human chondrocyte cell lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Safety & Documentation

Safety Information

WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles


Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
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Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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