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AB3610 Sigma-Aldrich

Anti-Survivin Antibody

This Anti-Survivin Antibody is validated for use in WB, IP, IH for the detection of Survivin.

Synonym: TIAP

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Properties

Related Categories Antibodies, Primary Antibodies More...
trade name   Chemicon
brand family   Chemicon
format   Serum
application(s)   Western Blotting
  Immunoprecipitation
  Immunohistochemistry
clone   Polyclonal Antibody
host   Rabbit
species reactivity   Human
NCBI accession no.   NM_001012270.1, NM_001012271.1, NM_001168.2
UniProt accession no.   O15392
gene symbol   BIRC5(332)
  API4
  EPR-1
  IAP4
  SURVIVIN
  SVV
material size   100 µL
shipped in   wet ice
storage conditions   Maintain at -20°C for up to 6 months after date of receipt.

Description

Background information

Apoptosis is triggered by a variety of stimuli, including members of the Tumor Necrosis Factor (TNF) family, and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. One of these IAP proteins, Survivin/TIAP, interacts with the processed form of caspase-3 and has been shown to inhibit its proteolytic activity. Survivin/TIAP is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas.

Physical form

Serum with no preservatives

Application

Immunoblotting: Recommended antibody dilution 1:3000-6000

Immunoprecipitation: Recommended antibody dilution 1:200

Immunohistochemisty: Recommended antibody dilution 1:1500

Optimal antibody dilutions must be determined by end-user.

Specificity

Detects mouse survivin/TIAP in an approximate 17 kDa band by western blot.

Immunogen

Recombinant, GST-tagged full length human Survivin

Usage Statement

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
Protocols & Articles

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

Peer-Reviewed Papers
15

References

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