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AB6030 Sigma-Aldrich

Anti-Integrin alpha 10 (ITGA10) Antibody

from rabbit, purified by affinity chromatography

Synonym: Integrin, alpha 10, integrin alpha-10

  •  eCl@ss 32160702

  •  NACRES NA.41

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Properties

Related Categories Alphabetical Index, Antibodies, IN-IP, Primary Antibodies
clone   polyclonal
biological source   rabbit
application(s)   western blot: suitable
species reactivity   human, chimpanzee, primate, pig, canine, human, rhesus macaque
species reactivity (predicted by homology)   pig (based on 100% sequence homology), rhesus monkey (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), canine (based on 100% sequence homology)
shipped in   wet ice
Quality Level   100
antibody product type   primary antibodies
purified by   affinity chromatography
NCBI accession no.   NP_003628
UniProt accession no.   O75578
Gene Information   human ... ITGA10(8515)

Description

General description

Integrins are transmembrane proteins that are involved in interactions cell-to-cell and cell-to-extracellular matrix (ECM) adhesion. Integrins play diverse roles including cell migration, development, wound healing, differentiation, and apoptosis. Integrin alpha 10 subunit (ITGA10), along with integrin beta 1, is thought to be an essential part of a novel collagen type II receptor expressed mainly in chondrocytes and cartilage tissue.

Specificity

Other homologies: rat (93% sequence homology).

This antibody recognizes the extracellular domain of Integrin alpha 10.

Immunogen

Epitope: Extracellular Domain

KLH-conjugated linear peptide corresponding to the extracellular domain of human Integrin alpha-10.

Application

Detect Integrin alpha 10 (ITGA10) using this Anti-Integrin alpha 10 (ITGA10) Antibody validated for use in WB.

Research Category
Cell Structure

Research Sub Category
Integrins

Adhesion (CAMs)

Target description

~127 kDa observed

Physical form

Affinity Purfied

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Quality

Evaluated by Western Blot in SW-1353 cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected integrin alpha10 in 10 µg of SW-1353 cell lysate.

Analysis Note

Control
SW-1353 cell lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Safety & Documentation

Safety Information

WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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