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  • MAB1914P - Anti-Laminin gamma 1 Antibody, clone A5

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MAB1914P Sigma-Aldrich

Anti-Laminin gamma 1 Antibody, clone A5

Detect Laminin gamma 1 using this Anti-Laminin gamma 1 Antibody, clone A5 validated for use in IH(P).

Synonym: LAMC1

  •  eCl@ss 32160702

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Properties

Related Categories Antibodies, Primary Antibodies More...
gene symbol   LAMC1(3915)
UniProt accession no.   P11047
application(s)   Immunohistochemistry (Paraffin)
brand family   Chemicon
clone   A5
  Monoclonal Antibody
concentration   Please refer to the Certificate of Analysis for the lot-specific concentration.
format   Purified
host   Rat
isotype   IgG2aκ
molecular weight   177 kDa
packaging   100 µL (MAB1914P)
shipped in   wet ice
species reactivity   Human, Mouse
trade name   Chemicon

Description

Analysis Note

Control
Tubular carcinoma of the colon and fibroneuroma

Application

Research Sub Category
ECM Proteins

Adhesion (CAMs)

General description

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Variations in the expression of laminins have been observed in embryogenesis, organogenesis, post traumatic healing and cancer. Laminins have been provoked by the discovery of their ability to promote neurite regeneration. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively). The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly.

Immunogen

Basement membrane protein preparation from mouse EHS tumor.

Physical form

Purified rat immunoglobulin in buffer containing 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
Protocols & Articles
Peer-Reviewed Papers
15

References

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