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  • MAB312RX - Anti-Neuron Cell Surface Antigen Antibody, clone A2B5-105 (7), Alexa Fluor 488

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MAB312RX Sigma-Aldrich

Anti-Neuron Cell Surface Antigen Antibody, clone A2B5-105 (7), Alexa Fluor 488

Anti-Neuron Cell Surface Antigen Antibody, clone A2B5-105 (7), Alexa Fluor 488 detects level of Neuron Cell Surface Antigen & has been published & validated for use in IC, IH.

Synonym: A2B5

  •  eCl@ss 32160702

  •  NACRES NA.41

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Properties

Related Categories Alphabetical Index, Antibodies, NE-NI, Primary Antibodies
conjugate   ALEXA FLUOR® 488
clone   A2B5-105 (7), monoclonal
biological source   mouse
application(s)   immunocytochemistry: suitable
  immunohistochemistry: suitable
species reactivity   rat, chicken, mouse, human
shipped in   wet ice
isotype   IgM
antibody product type   primary antibodies
mfr. no.   Chemicon®

Description

Specificity

The antibody recognizes an epitope common to silaogangliosides and sulfatides from the plasma membranes of neurons, and neuroendocrine and glial cells. Anti-A2B5 has been used to specifically stain:

· Neurofibrillary tangles in the post-mortem brain tissue of patients with a confirmed diagnosis of Alzheimer′s disease (Majocha et al., 1989)

· Neurons of chicken retina, brain, spinal cord, and dorsal root ganglia (Schnitzer & Schachner, 1982; Eisenbarth et al., 1979.

· Rat striatal nerve terminals [synaptosomes (Wolf & Kapatos, 1989].

· Neuroblastoma cells in man (Oppedal et al., 1989; Coakham et al., 1985).

· Rat insulinoma cells and pancreatic islets cells (Shimizu et al., 1983; Bartholomeusz et al., 1989).

· Human and rat thymic epithelial cells (Haynes, et al., 1988).

· Cells involved in gliogenesis (Bottenstein et al., 1988; Suzumura & slerberg, 1989).

· Oligodendrocytes and astrocytes, type II (Dubois-Dalcq et al., 1990).

Immunogen

Embryonic chicken retinal cells

Application

Immunocytochemistry

Immunohistochemistry: 1:30

Optimal working dilutions must be determined by end user.

Research Category
Neuroscience

Research Sub Category
Neuronal & Glial Markers

Physical form

Purified immunoglobulin conjugated to Alexa Fluor® 488. Liquid in Phosphate buffer with 15 mg/mL BSA as a stabilizer and 0.1% sodium azide.

Storage and Stability

Maintain at 2-8°C in undiluted aliquots in the dark for up to 6 months after date of receipt.

Disclaimer

Alexa Fluor® is a registered trademark of Molecular Probes, Inc.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Legal Information

ALEXA FLUOR is a registered trademark of Life Technologies

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles

Articles

Antibody Basics

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Peer-Reviewed Papers
15

References

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