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  • MABE933 - Anti-Tudor-SN Antibody, clone 13.14.1

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MABE933 Sigma-Aldrich

Anti-Tudor-SN Antibody, clone 13.14.1

clone 13.14.1, 1 mg/mL, from mouse

Synonym: Staphylococcal nuclease domain-containing protein 1, 100 kDa coactivator, EBNA2 coactivator p100, Tudor domain-containing protein 11, p100 co-activator, Tudor-SN

  •  eCl@ss 32160702

  •  NACRES NA.41

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Properties

Related Categories Alphabetical Index, Antibodies, Primary Antibodies, TS-TZ
clone   13.14.1, monoclonal
biological source   mouse
application(s)   western blot: suitable
species reactivity   human
shipped in   wet ice
isotype   IgG1κ
Quality Level   300
antibody product type   primary antibodies
concentration   1 mg/mL
NCBI accession no.   NP_055205
UniProt accession no.   Q7KZF4
Gene Information   human ... SND1(27044)

Description

General description

Tudor-SN, also known as Staphylococcal nuclease domain-containing protein 1, 100 kDa coactivator or EBNA2 coactivator p100 or Tudor domain-containing protein 11 or p100 co-activator, and encoded by the gene name SND1 or TDRD11, plays an important role in PIM1 regulation of MYB acitivity and acts as a transcriptional activatior of EBNA-2. SND1 also interacts with EAV, NSP1,GTF2E1 and GTF2E2, and forms a ternary complex with STAT6 and POLR2A. SND1 ic localized to the cytoplasm and in IL-4 stimulated cells SND1 co-localizes with STAT6 in the nucleus. SND1 plays an important role in the assembly of STAT6 transcriptome and stimulates IL-4-dependent transcription by mediating interaction between STAT6 and CBP.

Immunogen

Epitope: C-terminus

Recombinant protein corresponding to the C-terminus of human Tudor-SN.

Application

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Nuclear Receptors

This Anti-Tudor-SN Antibody, clone 13.14.1 is validated for use in Western Blotting for the detection of Tudor-SN.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Tudor-SN in 10 µg of HeLa cell lysate.
Western Blotting Analysis: A representative lot detected Tudor-SN in HeLa and Hek 293 cell lysate (Ota, H., et al. (2013). Cell. 153:575-589).

Target description

~110 kDa observed. The calculated molecular weight of this protein is 101 kDa, but can be observed at ~110 kDa due to post transitional modifications.

Physical form

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Quality

Evaluated by Western Blotting in HEK-293 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Tudor-SN in 10 µg of HEK-293 cell lysate.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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