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  • MABF12 - Anti-Interleukin-17 (IL-17) Antibody, clone 1C12

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MABF12 Sigma-Aldrich

Anti-Interleukin-17 (IL-17) Antibody, clone 1C12

Synonym: interleukin 17A, interleukin-17A, interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8), cytotoxic T-lymphocyte-associated serine esterase 8, Cytotoxic T-lymphocyte-associated antigen 8, cytotoxic T-lymphocyte-associated protein 8

  •  eCl@ss 32160702

  •  NACRES NA.41

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Properties

Related Categories Antibodies, Antibodies for Cell Biology, Antibodies for Neurobiology, Antibodies to Chemokines, Antibodies to Cytokines and Growth Factors,
biological source   mouse
clone   AB44.57.27E4.1C12, monoclonal
species reactivity   human
application(s)   western blot: suitable
isotype   IgG2aκ
NCBI accession no.   NP_002181
UniProt accession no.   Q16552
shipped in   wet ice

Description

General description

Interleukin-17 (IL-17) is known to stimulate the transcription factor nuclear factor (NF)-kappaB and c-Jun NH(2)-terminal kinase. TRAF6 is essential in the IL-17 signaling pathway of proinflammatory response. Over-expression of IL-17 by T cells seems to be important in systemic sclerosis pathogenesis. IL-17 is particularly involved in early development of the disease by activating fibroblast propagation and creation of IL-1. IL-17 connects lymphoid and myeloid host defenses and so plays an essential part in the microbial defense response. IL-17 also seems to support the innate immune response by mobilizing neutrophils. IL-17 may be an important clinical target for allergic airway disease.

Immunogen

Cohesin-tagged recombinant protein corresponding to human IL-17.

Quality

Evaluated by Western Blot in lysate from cells expressing human IL-17 recombinant protein.

Western Blot Analysis: 0.5 µg/mL of this antibody detected 10 µg of human IL-17 recombinant protein.

Target description

~15 kDa observed

Linkage

Replaces: 04-464

Physical form

Format: Purified

Analysis Note

Control
Human IL-17 recombinant protein.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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