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MABF12 Sigma-Aldrich

Anti-Interleukin-17 (IL-17) Antibody, clone 1C12

Anti-Interleukin-17 (IL-17) Antibody, clone 1C12 is an antibody against Interleukin-17 (IL-17) for use in WB.

Synonym: interleukin 17A, interleukin-17A, interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8), cytotoxic T-lymphocyte-associated serine esterase 8, Cytotoxic T-lymphocyte-associated antigen 8, cytotoxic T-lymphocyte-associated protein 8

  •  eCl@ss 32160702

  •  NACRES NA.41

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Properties

Related Categories Antibodies, Antibodies for Cell Biology, Antibodies for Neurobiology, Antibodies to Chemokines, Antibodies to Cytokines and Growth Factors,
packaging   100 µg (MABF122)
application(s)   western blot: suitable
biological source   mouse
clone   AB44.57.27E4.1C12, monoclonal
isotype   IgG2aκ
shipped in   wet ice
species reactivity   human
gene symbol   IL17A(3605)
format   Purified
molecular weight   ~15 kDa observed
clone   Monoclonal Antibody
concentration   Please refer to the Certificate of Analysis for the lot-specific concentration.
gene symbol   CTLA-8
  CTLA8
  IL-17
  IL-17A
  IL17
Quality Assurance   Evaluated by Western Blot in lysate from cells expressing human IL-17 recombinant protein.

Western Blot Analysis: 0.5 µg/mL of this antibody detected 10 µg of human IL-17 recombinant protein.

Description

Target description

~15 kDa observed

Analysis Note

Control
Human IL-17 recombinant protein.

General description

Interleukin-17 (IL-17) is known to stimulate the transcription factor nuclear factor (NF)-kappaB and c-Jun NH(2)-terminal kinase. TRAF6 is essential in the IL-17 signaling pathway of proinflammatory response. Over-expression of IL-17 by T cells seems to be important in systemic sclerosis pathogenesis. IL-17 is particularly involved in early development of the disease by activating fibroblast propagation and creation of IL-1. IL-17 connects lymphoid and myeloid host defenses and so plays an essential part in the microbial defense response. IL-17 also seems to support the innate immune response by mobilizing neutrophils. IL-17 may be an important clinical target for allergic airway disease.

Immunogen

Cohesin-tagged recombinant protein corresponding to human IL-17.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Format: Purified

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis

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Protocols & Articles

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

Peer-Reviewed Papers
15

References

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