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MABF331 Sigma-Aldrich

Anti-IL-17A (human) Antibody, PE, clone BL168

Anti-IL-17A (human) Antibody, PE, clone BL168 is a highly specific mouse monoclonal antibody & that targets IL-17 & has been tested in Flow Cytometry.

Synonym: Interleukin-17A, IL-17, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8, CTLA-8

  •  eCl@ss 32160702

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Properties

Related Categories Antibodies, Primary Antibodies More...
packaging   100 tests (MABF331)
gene symbol   IL17A(3605)
format   PE
molecular weight   18 kDa calculated
application(s)   Flow Cytometry
isotype   IgG1κ
clone   Monoclonal Antibody
  BL168
concentration   Please refer to the Certificate of Analysis for the lot-specific concentration.
host   Mouse
species reactivity   Human
gene symbol   CTLA8
  IL17
UniProt accession no.   Q16552
shipped in   1
Quality Assurance   The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Flow Cytometry Analysis: 5 μL of this antibody detected IL-17A in one million human peripheral blood lymphocytes.

Description

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Application

Research Category
Inflammation & Immunology

Research Sub Category
Cytokines & Cytokine Receptors

General description

IL-17A is a member of the IL-17 family, a group of six structurally related pro-inflammatory cytokines. IL-17A, secreted by activated CD4+ Th17 cell subpopulation, plays an important role in many biological activities on a variety of cells including: the induction of IL-6, IL-8, G-CSF, and PGE2 production in epithelial, endothelial or fibroblasts; the enhancement of surface expression of ICAM-1 in fibroblasts; activation of NF-kB and co-stimulation of T cell proliferation. Recent studies demonstrated that, in mice, activated IL-17-secreting CD4+ helper T cells (Th17 cells) mediate an autoimmune arthritis that clinically and immunologically resembles rheumatoid arthritis (RA). Human IL-17A shows 63%, 63%, and 72% amino acid sequence identity to rat IL-17A, mouse IL-17A, and a protein encoded by the ORF13 gene of herpesvirus Saimiri (HVS), respectively. IL-17A is specific to and restricted to activated memory T-cells.

Immunogen

Recombinant full length human IL-17A

Physical form

Affinity

Purified mouse conjugate antibody in buffer containing PBS (pH 7.2) with up to 0.1% sodium azide and 0.2% (w/v) BSA.

Storage and Stability

The antibody solution should be stored undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
Protocols & Articles
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