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10107409001 Roche

Mitomycin C

Synonym: Mitomycin C

  • CAS Number 50-07-7

  • Empirical Formula (Hill Notation) C15H18N4O5

  • Molecular Weight 334.33

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Properties

Related Categories Antibiotics, Antibiotics by Mechanism of Action, Biochemicals and Reagents, Interferes with DNA Synthesis
Quality Level   100
assay   98%
mol wt   334.3
packaging   pkg of 2 mg
mfr. no.   Roche
Mode of action   DNA synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
shipped in   wet ice
storage temp.   2-8°C
InChI   1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1
InChI key   NWIBSHFKIJFRCO-WUDYKRTCSA-N

Description

General description

Mitomycin C is an antitumor antibiotic.

Application

Mitomycin C has been used:
•  to cease mitosis
• in phosphate buffer saline (PBS) for inactivation and plating mouse embryonic fibroblasts (MEFs)
• as mutagen in mutagenicity assay

Mitomycin C is used as an inhibitor for studies of cell-free protein biosynthesis. It also inhibits DNA synthesis. It has been used as a genotoxic agent for tumor cells.

Biochem/physiol Actions

Mitomycin C (MMC) acts as a prototype for drugs with bioreductive alkylation. It is mainly found to be active under anaerobic conditions. MMC exhibits a vast clinical antitumor spectrum effectively in gastric, pancreatic and breast cancer.

Other Notes

For life science research only. Not for use in diagnostic procedures.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
WGK 3
Flash Point(F) 
does not flash
Flash Point(C) 
does not flash

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Antibiotic Kill Curve

Antibiotic kill curve is a dose response experiment in which mammalian cells are subjected to increasing amounts of selection antibiotic to determine the minimum concentration of an antibiotic that c...
Keywords: Antibiotics, Cell culture, Evaporation, Transfection

Peer-Reviewed Papers
15

References

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