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05-0370 Sigma-Aldrich

Caffeine

SAJ special grade, ≥98.5%

Synonym: 1,3,7-Trimethylxanthine

  • CAS Number 58-08-2

  • Empirical Formula (Hill Notation) C8H10N4O2

  • Molecular Weight 194.19

  •  Beilstein/REAXYS Number 17705

  •  EC Number 200-362-1

  •  MDL number MFCD00005758

  •  PubChem Substance ID 329748014

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Properties

Related Categories Alkaloid, Anti-Proliferative Agents, Antitumor Agents, Cancer Research, Cell Biology,
grade   SAJ special grade
InChI Key   RYYVLZVUVIJVGH-UHFFFAOYSA-N
assay   ≥98.5%
form   crystalline
  powder
availability   not available in Japan
mp   234-236.5 °C (lit.)
solubility   H2O: soluble 18.7 g/L at 16 °C
Gene Information   human ... ADORA1(134), PDE4B(5142)

Description

Biochem/physiol Actions

A central nervous system stimulant believed to act through adenosine receptors and monoamine neurotransmitters. It is an adenosine receptor antagonist and adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. Thus, levels of cAMP increase in cells following treatment with caffeine. It has been reported to affect cellular calcium levels, releasing calcium from intracellular stores. It overrides the cell cycle effects of various chemicals such as protease inhibitors, preventing apoptosis; and it has been shown to inhibit cellular DNA repair mechanisms.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
1
RTECS 
EV6475000

Documents

Certificate of Analysis

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Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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