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Curcumin

primary reference standard

Synonym: (E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Diferuloylmethane, Diferulylmethane, Natural Yellow 3

  • CAS Number 458-37-7

  • Linear Formula [HOC6H3(OCH3)CH=CHCO]2CH2

  • Molecular Weight 368.38

  •  Colour Index Number 75300

  •  Beilstein Registry Number 2306965

  •  EC Number 207-280-5

  •  MDL number MFCD00008365

  •  PubChem Substance ID 329747028

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Description

Application

It has been used as reference standard in 1H NMR and LC–MS/MS analysis for the quantification of curcumin in turmeric.

Reference Standard in the analysis of herbal medicinal products

Biochem/physiol Actions

A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Curcumin has been cited as a potential chemopreventive agent, in addition to its chemotherapeutic activity. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.

General description

Curcumin is a bioactive component of turmeric, Curcuma longa. It has a broad spectrum of activities including antioxidant, anti-inflammatory and being anti-cancerous in nature. It has been shown to be a very powerful antioxidant, and has been found to enhance the effects of common anti-cancer drugs. It can also modulate several molecular targets such as cytokines and chemokines, a multitude of enzymes, receptors, transcription factors, cell cycle proteins and cell surface adhesion molecules.

Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
MI5230000
Protocols & Articles

Articles

UHPLC Analysis of Curcumins on Ascentis® Express RP-Amide

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Curcumins on Ascentis® Express RP-Amide
Keywords: Vitamins

UHPLC Analysis of Turmeric Curcumin Herbal Supplement on Ascentis® Express RP-Amide

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Turmeric Curcumin Herbal Supplement on Ascentis® Express RP-Amide
Keywords: Chromatography, Sample preparations, Vitamins

UHPLC Analysis of Turmeric Standards on Ascentis® Express RP-Amide

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Turmeric Standards on Ascentis® Express RP-Amide
Keywords: Chromatography, Vitamins

Peer-Reviewed Papers
15

References

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