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01760595 Sigma-Aldrich

Apigenin

primary reference standard

Synonym: 4′,5,7-Trihydroxyflavone, 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone

  • CAS Number 520-36-5

  • Empirical Formula (Hill Notation) C15H10O5

  • Molecular Weight 270.24

  •  Beilstein/REAXYS Number 262620

  •  EC Number 208-292-3

  •  MDL number MFCD00006831

  •  PubChem Substance ID 329747355

  •  NACRES NA.24

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Properties

Related Categories A - D, Achillea, Alphabetical Index of Phytochemical Standards, Analytical Standards, Analytical/Chromatography,
grade   primary reference standard
InChI Key   KZNIFHPLKGYRTM-UHFFFAOYSA-N
CofA   certificate is enclosed in each package
shelf life   limited shelf life, expiry date on the label
mp   >300 °C (lit.)
Featured Industry   Food and Beverages

Description

General description

Flavonoids belong to polyphenolic class of compounds. They play crucial role in biological activities which include tumor growth inhibition and chemoprevention. Apigenin is a plant flavonoid mostly used to inhibit ornithine decarboxylase activity and skin tumor.

Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.

Application

It may be used as internal standard for determining peurarin and its metabolites, using LC-ESI-MS/MS, in blood and urine of rats.

Biochem/physiol Actions

A plant flavonoid that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. Inhibition of growth through cell cycle arrest and induction of apoptosis appear to be related to induction of p53. Inhibits PMA-mediated tumor promotion by inhibiting protein kinase C and the resulting suppression of oncogene expression. It has also been reported to inhibit topoisomerase I-catalyzed DNA re-ligation and enhance gap junctional intercellular communication.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
LK9276000
Protocols & Articles

Articles

HPTLC Application for Passiflora incarnata

In previous articles we presented HPTLC (High- Performance Thin-Layer Chromatography) applications for a series of medicinal plants, such as Ginkgo (Analytix 5/2016), Hypericum (Analytix 1/2017) or G...
Keywords: Chromatography, Derivatizations, Sample preparations, Solvents, Thin layer chromatography

Peer-Reviewed Papers
15

References

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