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Dansyl chloride

for HPLC derivatization, LiChropur, ≥99.0% (HPLC)

Synonym: 5-(Dimethylamino)naphthalene-1-sulfonyl chloride, DNSCl

  • CAS Number 605-65-2

  • Empirical Formula (Hill Notation) C12H12ClNO2S

  • Molecular Weight 269.75

  •  Beilstein/REAXYS Number 2217205

  •  EC Number 210-092-6

  •  MDL number MFCD00003985

  •  PubChem Substance ID 329747747

  •  NACRES NA.22

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Properties

Related Categories Analytical Reagents, Analytical/Chromatography, Derivatization Reagents, Derivatization Reagents HPLC, Mass Spectrometry More...
grade   for HPLC derivatization
InChI Key   XPDXVDYUQZHFPV-UHFFFAOYSA-N
assay   ≥99.0% (HPLC)
quality   LiChropur
mp   72-74 °C (lit.)
solubility   acetone: 0.2 g/10 mL, clear to slightly turbid, yellow to very dark yellow-orange
storage temp.   2-8°C

Description

General description

Dansyl chloride is a fluorogenic reagent which is typically employed for the derivatization of amino acids.

Application

Dansyl chloride has been used for the fluorogenic labeling of xenoestrogens, 4-nonylphenol and bisphenol A prior to their determination by high-performance liquid chromatography (HPLC) with fluorescence detection. It has also been used for the derivatization of icariin in human serum samples after oral administration of Epimedium decoction, followed by its determination using ultrasensitive LC-tandem mass spectrometry (LC-MS) and for the derivatization of antitumoral agent ES-285 in dog plasma followed by its analysis by HPLC equipped with ultraviolet and fluorescence detection.

A fluorogenic reagent for fluorescent N-terminal derivatization of amino acids and peptides and detection by reverse phase HPLC.

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Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3261 8 / PGII
WGK Germany 
3
RTECS 
QK3688000

Documents

Certificate of Analysis

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Protocols & Articles
Peer-Reviewed Papers
15

References

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