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04573 Sigma-Aldrich

Thiamine hydrochloride

tested according to Ph Eur

Synonym: Aneurine hydrochloride, Thiamio hydrochloridum, Vitamin B1 hydrochloride

  • CAS Number 67-03-8

  • Empirical Formula (Hill Notation) C12H17ClN4OS · HCl

  • Molecular Weight 337.27

  •  Beilstein/REAXYS Number 3851771

  •  EC Number 200-641-8

  •  MDL number MFCD00012780

  •  eCl@ss 34058006

  •  PubChem Substance ID 329747946

  •  NACRES NA.26

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Properties

Related Categories Asymmetric Synthesis, Biochemicals and Reagents, Chemical Synthesis, Chiral Building Blocks, Complex Molecules,
Quality Level   200
biological source   synthetic
Agency/Method   tested according to Ph Eur
assay   98.5-101.0% anhydrous basis
form   solid
mp   250 °C (dec.) (lit.)
solubility   alcohol: soluble 1 gm in 100 ml (95%)
  alcohol: soluble 1 gm in 315 ml (Absolute)
  glycerol: soluble 1 gm in 18 ml
  water: soluble 1 g/mL
  benzene: insoluble
  chloroform: insoluble
  diethyl ether: insoluble
  hexane: insoluble
  methanol: very soluble
  propylene glycol: soluble
storage temp.   2-8°C
SMILES string   CC1=NC(N)=C(C[N+]2=CSC(CCO)=C2C)C=N1.Cl.[Cl-]
InChI   1S/C12H17N4OS.2ClH/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;;/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);2*1H/q+1;;/p-1
InChI key   DPJRMOMPQZCRJU-UHFFFAOYSA-M

Description

Application

Thiamine hydrochloride has been used as a keratin salts medium supplement for culturing log-phase fungus. It has also been used as a supplement of VB medium the minimal medium of Vogel and Bonner.

Biochem/physiol Actions

Thiamine hydrochloride is a cheap, non-toxic and efficient catalyst for the synthesis of amidoalkyl naphthols. It inhibits the production of shikonin derivatives by suspension cultures of Lithospermum erythrorhizon. Additionally, thiamine hydrochloride addition to apple juice concentrates reduces its patulin content.

Thiamine hydrochloride is a hydrochloride salt form of thiamine (Vitamin B1). It is crucial for aerobic metabolism, cell growth, transmission of nerve impulses and acetylcholine synthesis.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
RTECS 
XI7350000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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