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08471 Supelco

Dichlorodimethylsilane solution

~5% in toluene, for GC derivatization, LiChropur

Synonym: Dimethyldichlorosilane solution, Sylon CT

  • CAS Number 75-78-5

  • Empirical Formula (Hill Notation) C2H6Cl2Si

  • Molecular Weight 129.06

  •  Beilstein/REAXYS Number 605287

  •  MDL number MFCD00000491

  •  NACRES NA.22



Related Categories Analytical Reagents, Analytical/Chromatography, Derivatization Reagents, Derivatization Reagents GC, Reagents for Silylation,
Quality Level   100
grade   for GC derivatization
quality   LiChropur
concentration   ~5% in toluene
refractive index   n20/D 1.491-1.495
reaction suitability   reagent type: derivatization reagent
reaction type: Silylations


General description

For deactivating glassware.
Treat the glass tubing that you use for columns with Sylon-CT solution (5% dimethyldichlorosilane in toluene). It deactivates the tubing for use up to 350 °C to 400 °C, far exceeding the capabilities of other deactivating agents used at room temperature. Sylon CT also deactivates transfer lines and glass or glass-lined injection port liners. Instructions included.


Sylon CT was used as derivatizing agent, during an experiment to develop sensitive GC method for the identification and determination of long-chain primary alkyl amines.† It was also used for treating Erlenmeyer flasks to prevent mycelium from sticking to the glassware during development of techniques in the identification and partial characterization the chaxamycin biosynthesis gene cluster of S. leeuwenhoekii.†

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Sylon CT is a trademark of Sigma-Aldrich Co. LLC

Sylon is a trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

UN 2920 3(8) / PGI
Protocols & Articles


Silylating Reagents for GC-MS Compatible Derivatives of NSAIDs

Human and veterinary pharmaceuticals are a group of “emerging” contaminants,1, 2 some of which are produced in increasingly large volumes every year. The amounts produced are reaching quantities simi...
Luis-Alberto Martin
AnalytiX Volume 10 Article 2
Keywords: Anti-inflammatory agents, Derivatizations, Environmental, Gas chromatography, Gas chromatography mass spectrometry, Mass spectrometry, Metabolites, Pesticides, Pharmaceutical, Silylations, Veterinary

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