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Curcumin

analytical standard

Synonym: (E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Diferuloylmethane, Diferulylmethane, Natural Yellow 3

  • CAS Number 458-37-7

  • Linear Formula [HOC6H3(OCH3)CH=CHCO]2CH2

  • Molecular Weight 368.38

  •  Colour Index Number 75300

  •  Beilstein Registry Number 2306965

  •  EC Number 207-280-5

  •  MDL number MFCD00008365

  •  PubChem Substance ID 329748594

  •  E Number E100

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Properties

Related Categories A - D, Additional Standards, All Alphabetically Sorted, All alphabetical sorted, Alphabetical Index of Phytochemical Standards,
grade   analytical standard
vapor density   13 (vs air)
InChI Key   VFLDPWHFBUODDF-FCXRPNKRSA-N
assay   ≥98.0% (HPLC)
form   powder
shelf life   limited shelf life, expiry date on the label
Featured Industry   Cosmetics, Personal Care, and Cleaning Products
Food and Beverages
storage temp.   2-8°C

Description

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Application

Curcumin may be used as a reference standard for the determination of curcumin in rat plasma by high-performance liquid chromatography method.

Biochem/physiol Actions

A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Curcumin has been cited as a potential chemopreventive agent, in addition to its chemotherapeutic activity. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.

General description

Curcumin is an anti-inflammatory agent extracted from the roots of Curcuma longa Linn.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
MI5230000

Same Products - New Packaging
Protocols & Articles

Articles

UHPLC Analysis of Curcumins on Ascentis® Express RP-Amide

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Curcumins on Ascentis® Express RP-Amide
Keywords: Vitamins

UHPLC Analysis of Turmeric Curcumin Herbal Supplement on Ascentis® Express RP-Amide

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Turmeric Curcumin Herbal Supplement on Ascentis® Express RP-Amide
Keywords: Chromatography, Sample preparations, Vitamins

UHPLC Analysis of Turmeric Standards on Ascentis® Express RP-Amide

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Turmeric Standards on Ascentis® Express RP-Amide
Keywords: Chromatography, Vitamins

Peer-Reviewed Papers
15

References

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