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09935 Sigma-Aldrich

Ammonium pyrrolidinedithiocarbamate

purum p.a., ≥98.0% (NT)

Synonym: 1-Pyrrolidinecarbodithioic acid ammonium salt, APDC, Ammonium pyrrolidinecarbodithioate, PDC, PDTC

  • CAS Number 5108-96-3

  • Linear Formula C5H9NS2 · NH3

  • Molecular Weight 164.29

  •  Beilstein/REAXYS Number 3730472

  •  EC Number 225-834-4

  •  MDL number MFCD00012720

  •  PubChem Substance ID 329748864

  •  NACRES NA.21



Related Categories Ammonium Salts, Analytical Reagents, Analytical/Chromatography, Essential Chemicals, Gravimetric Reagents,
Quality Level   200
grade   purum p.a.
assay   ≥98.0% (NT)
mp   153-155 °C (lit.)
cation traces   Bi: ≤10 mg/kg
  Ca: ≤10 mg/kg
  Cd: ≤10 mg/kg
  Co: ≤10 mg/kg
  Cr: ≤10 mg/kg
  Cu: ≤10 mg/kg
  Fe: ≤10 mg/kg
  K: ≤50 mg/kg
  Mg: ≤10 mg/kg
  Mn: ≤10 mg/kg
  Na: ≤50 mg/kg
  Ni: ≤10 mg/kg
  Pb: ≤10 mg/kg
  Zn: ≤10 mg/kg
storage temp.   room temp
SMILES string   N.SC(=S)N1CCCC1
InChI   1S/C5H9NS2.H3N/c7-5(8)6-3-1-2-4-6;/h1-4H2,(H,7,8);1H3
Gene Information   human ... RELA(5970)


Other Notes

Reagent used for the extraction and pre-concentration of heavy metals with an organic solvent from aqueous solutions for atomic absorption spectroscopy, AAS. MIBK (methyl isobutyl ketone) is the solvent of choice; The extract can be directly injected into the flame

Safety & Documentation

Safety Information

Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Frequently Asked Questions

How does the storage temperature relate to shipping conditions?
The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment. See Shipping and Storage for more information.
Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
How can I dissolve Product 09935, Ammonium pyrrolidinedithiocarbamate?
Ammonium pyrrolidinedithiocarbamate is soluble in water at a concentration of approximately 50 mg/mL.
What is the solution stability of Product 09935, Ammonium pyrrolidinedithiocarbamate?
Sigma has not evaluated the solution stability of PDTC. However, aqueous stock solutions may be stable for at least one month when stored at -20 °C.
What are some functions reported for Product 09935, Ammonium pyrrolidinedithiocarbamate?
PDTC has been reported to repress vascular cell adhesion molecule-1 (VCAM-1) activation by Interleukin-1β in cultured human umbilical vein endothelial calls. Marui, M., et al., J. Clin. Invest, 92, 1866 (1993).It inhibits the induction of nitric oxide synthase activity in rat alveolar macrophages. Sherman, M.P., et al., Biochem. Biophys. Res. Commun. 191, 1301-1308 (1993).It is an Inhibitor of nuclear factor kappa B., Eberhardt, et al. Biochem. Biophys. Res. Commun. 200, 163 (1994). PDTC at 100μM, totally inhibited the NF-kappa B response in intact cells. Schreck, R., et al., J. Exp. Med. 175 , 1181-1194 (1992). It activates cAMP-dependent protein kinase (PKA) in a colorectal cancer cell line. Chinery, R., et al., J. Biol. Chem., 272, 30356 - 30361, (1997).
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