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15209 Supelco

N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane

for GC derivatization, LiChropur, contains 10% TMCS, 98% (excluding TMCS)

Synonym: BSTFA + TMCS

  • CAS Number 25561-30-2

  • Linear Formula CF3C[=NSi(CH3)3]OSi(CH3)3

  • Molecular Weight 257.40

  •  Beilstein/REAXYS Number 2050024

  •  MDL number MFCD00008269

  •  PubChem Substance ID 329750769

  •  NACRES NA.22

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Properties

Related Categories Analytical Reagents, Analytical/Chromatography, Biochemicals and Reagents, Carboxylic Acids, Derivatization Reagents,
Quality Level   100
grade   for GC derivatization
assay   ≥97.5% (excluding TMCS, GC)
  98% (excluding TMCS)
quality   LiChropur
reaction suitability   reagent type: derivatization reagent
reaction type: Silylations
application(s)   gas chromatography (GC): suitable
impurities   9.0-11.0% TMCS
refractive index   n20/D 1.384 (lit.)
bp   45-50 °C/14 mmHg (lit.)
density   0.97 g/mL (lit.)
SMILES string   C[Si](C)(C)O\C(=N\[Si](C)(C)C)C(F)(F)F
InChI   1S/C8H18F3NOSi2/c1-14(2,3)12-7(8(9,10)11)13-15(4,5)6/h1-6H3/b12-7+
InChI key   XCOBLONWWXQEBS-KPKJPENVSA-N

Description

General description

N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane has found application to be used in gas chromatography (GC) and mass-spectrometry (MS). It can also be used in HPLC- electrochemical detection assay of 8-oxo-deoxyguanosine and?8-oxo-guanine.

Packaging

10×1 mL in ampule

5 mL in glass bottle

Other Notes

The position of the silyl groups has not been unequivocally established. It has been referred to as both N,N and N,O.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2924 8(3) / PGII
WGK Germany 
WGK 3
Flash Point(F) 
15.8 °F - closed cup
Flash Point(C) 
-9 °C - closed cup
Protocols & Articles

Articles

Silylating Reagents for GC-MS Compatible Derivatives of NSAIDs

Human and veterinary pharmaceuticals are a group of “emerging” contaminants,1, 2 some of which are produced in increasingly large volumes every year. The amounts produced are reaching quantities simi...
Luis-Alberto Martin
AnalytiX Volume 10 Article 2
Keywords: Anti-inflammatory agents, Derivatizations, Environmental, Gas chromatography, Gas chromatography mass spectrometry, Mass spectrometry, Metabolites, Pesticides, Pharmaceutical, Silylations, Veterinary

Peer-Reviewed Papers
15

References

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