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N,O-Bis(trimethylsilyl)trifluoroacetamide

for GC derivatization, LiChropur, ≥99.0%

Synonym: BSTFA

  • CAS Number 25561-30-2

  • Linear Formula CF3C[=NSi(CH3)3]OSi(CH3)3

  • Molecular Weight 257.40

  •  Beilstein/REAXYS Number 2050024

  •  EC Number 247-103-9

  •  MDL number MFCD00008269

  •  PubChem Substance ID 329750779

  •  NACRES NA.22

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Properties

Related Categories Analytical Reagents, Analytical/Chromatography, Biochemicals and Reagents, Derivatization Reagents, Derivatization Reagents GC,
Quality Level   100
grade   for GC derivatization
assay   ≥99.0% (GC)
  ≥99.0%
quality   LiChropur
reaction suitability   reagent type: derivatization reagent
reaction type: Silylations
application(s)   gas chromatography (GC): suitable
refractive index   n20/D 1.384 (lit.)
  n20/D 1.384
bp   45-50 °C/14 mmHg (lit.)
density   0.969 g/mL at 25 °C (lit.)
SMILES string   C[Si](C)(C)O\C(=N\[Si](C)(C)C)C(F)(F)F
InChI   1S/C8H18F3NOSi2/c1-14(2,3)12-7(8(9,10)11)13-15(4,5)6/h1-6H3/b12-7+
InChI key   XCOBLONWWXQEBS-KPKJPENVSA-N

Description

General description

N,O-Bis(trimethylsilyl)trifluoroacetamide (BSTFA) is an excellent silylation reagent. For some sterically hindered primary or secondary nitro compounds, N,O-bis(trimethylsilyl)acetamide and BSTFA achieve better results than normal silylation conditions. BSTFA finds application in derivatizing amines. It is suitable for silyaltion of carboxylic acids, phenols, ureas, amides and alcohols.

Application

Learn more in the Product Information

BSTFA + 1% TMCS (trimethylsilyl) in ethyl acetate, acetonitrile and dichloromethane solvents may be used for silylation of steroid hormone 17a-ethinylestradiol (EE2) using gas chromatography-mass spectrometry (GC-MS). It may also be used for silylation of endogenous 2-monoglyceride, present in canine gut that binds to cannabinoid receptors.

Packaging

1, 10×1, 5, 25 mL in glass bottle

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
RIDADR 
UN 2924 8(3) / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
93.2 °F
Flash Point(C) 
34 °C
Protocols & Articles

Articles

Silylating Reagents for GC-MS Compatible Derivatives of NSAIDs

Human and veterinary pharmaceuticals are a group of “emerging” contaminants,1, 2 some of which are produced in increasingly large volumes every year. The amounts produced are reaching quantities simi...
Luis-Alberto Martin
AnalytiX Volume 10 Article 2
Keywords: Anti-inflammatory agents, Derivatizations, Environmental, Gas chromatography, Gas chromatography mass spectrometry, Mass spectrometry, Metabolites, Pesticides, Pharmaceutical, Silylations, Veterinary

Peer-Reviewed Papers
15

References

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