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16033 Sigma-Aldrich

1,2-Propanediol

meets analytical specification of Ph. Eur., BP, USP, ≥99.5%

Synonym: 1,2-PDO, Propylene glycol

  • CAS Number 57-55-6

  • Linear Formula CH3CH(OH)CH2OH

  • Molecular Weight 76.09

  •  Beilstein/REAXYS Number 1340498

  •  EC Number 200-338-0

  •  MDL number MFCD00064272

  •  PubChem Substance ID 57647543

  •  NACRES NA.21

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Properties

Quality Level   200
vapor density   2.62 (vs air)
vapor pressure   0.08 mmHg ( 20 °C)
assay   ≥99.5%
form   liquid
autoignition temp.   779 °F
quality   meets analytical specification of Ph. Eur., BP, USP
shelf life   24 mo.
expl. lim.   12.5 %
impurities   acidic reac. impurities, complies
  organic volatile impurities, complies (GC)
  oxidizing substances, complies
  reducing matter, complies
  residual solvents, complies
  ≤0.0005% heavy metals (as Pb)
  ≤0.002% free alkali (as NaOH)
  ≤0.003% free acid (as CH3COOH)
  ≤0.2% water (Karl Fischer)
ign. residue   ≤0.005% (as SO4)
refractive index   n20/D 1.431-1.433
  n20/D 1.432 (lit.)
bp   187 °C (lit.)
mp   −60 °C (lit.)
density   1.036 g/mL at 25 °C (lit.)
anion traces   chloride (Cl-): ≤50 mg/kg
  sulfate (SO42-): ≤50 mg/kg
suitability   complies for appearance of solution
SMILES string   CC(O)CO
InChI   1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3
InChI key   DNIAPMSPPWPWGF-UHFFFAOYSA-N

Description

General description

1,2-Propanediol is an 1,2-alkanediol. It can be obtained from glycerol, via hydrogenolysis in the presence of Ru/C and Amberlyst ion-exchange resins.

1,2-Propanediol is an important petrochemical that can be prepared by the hydrogenolysis of glycerol. It is mainly used as a cryoprotectant for biological samples and also as an additive in food, cosmetic and pharmaceutical industries.

Application

1,2-Propanediol may be employed as a cryoprotective agent for the preservation (by cooling to sub-zero temperatures) of human embryos and and oocytes (human and mouse).

Packaging

bottled under inert gas

Other Notes

The article number 16033-4X5L will be discontinued. Please order the single bottle 16033-5L which is physically identical with the same exact specifications.
The article number 16033-6X1L will be discontinued. Please order the single bottle 16033-1L which is physically identical with the same exact specifications.
The article number 16303-4X2.5L-R will be discontinued. Please order the single bottle 16303-2.5L-R which is physically identical with the same exact specifications.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
TY2000000
Flash Point(F) 
217.4 °F - closed cup
Flash Point(C) 
103 °C - closed cup
Protocols & Articles

Articles

GC Analysis of 1,2-Alkyldiol Enantiomers (O-Trifluoroacetyl Derivatives) on Astec® CHIRALDEX® G-TA

From our library of Articles, Sigma-Aldrich presents GC Analysis of 1,2-Alkyldiol Enantiomers (O-Trifluoroacetyl Derivatives) on Astec® CHIRALDEX® G-TA
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification

Peer-Reviewed Papers
15

References

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