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17849 Sigma-Aldrich

Enrofloxacin

≥99.0% (HPLC)

Synonym: Baytril

  • CAS Number 93106-60-6

  • Empirical Formula (Hill Notation) C19H22FN3O3

  • Molecular Weight 359.39

  •  Beilstein/REAXYS Number 5307824

  •  MDL number MFCD00792463

  •  PubChem Substance ID 329751571

  •  NACRES NA.21

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics by Mechanism of Action,
Quality Level   200
assay   ≥99.0% (HPLC)
  99.0-101.0% (dried substance)
form   powder or crystals
Mode of action   DNA synthesis | interferes
  enzyme | inhibits
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
SMILES string   CCN1CCN(CC1)c2cc3N(C=C(C(O)=O)C(=O)c3cc2F)C4CC4
InChI   1S/C19H22FN3O3/c1-2-21-5-7-22(8-6-21)17-10-16-13(9-15(17)20)18(24)14(19(25)26)11-23(16)12-3-4-12/h9-12H,2-8H2,1H3,(H,25,26)
InChI key   SPFYMRJSYKOXGV-UHFFFAOYSA-N

Description

General description

Chemical structure: fluoroquinolone

Enrofloxacin is a veterinary fluoroquinolone (FQ) antibiotic with broad-spectrum antimicrobial activity. FQ drugs chelate to iron with high affinity. This chelation leads to inhibition of Fe(II)-dependent dioxygenases involved in the regulation of epigenetic control, collagen maturation, and HIF (hypoxia-inducible factor) degradation. The side effects associated with FQ drugs are renal toxicity and tendinopathy. Enrofloxacin is used in aquaculture and its use may cause an increase in the growth of antibiotic resistant microbes in an aquatic environment. The drug may have negative effects on public health and environment.

Application

Enrofloxacin has been used:
• to investigate the pathological mechanisms resulting from the toxicity of fluoroquinolones in mammalian cells
• to prepare a standard solution with 50% acetonitrile in a study to analyze illegal fish drugs used in aquaculture by employing surface-enhanced Raman spectroscopy (SERS)
• as an analyte in a chemiluminescence reagent system

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
VB1993650
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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