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186562 Sigma-Aldrich

Tetrahydrofuran

anhydrous, contains 250 ppm BHT as inhibitor, ≥99.9%

Synonym: THF

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Properties

Related Categories Alternative Energy, Anhydrous, Anhydrous Solvents, Electrolytes, Lithium-Ion Batteries,
grade   anhydrous
vapor density   2.5 (vs air)
vapor pressure   114 mmHg ( 15 °C)
  143 mmHg ( 20 °C)
InChI Key   WYURNTSHIVDZCO-UHFFFAOYSA-N
assay   ≥99.9%
autoignition temp.   610 °F
contains   250 ppm BHT as inhibitor
expl. lim.   11.8 %
impurities   ≤0.005% peroxides (as H2O2)
  <0.002% water (All units except 100 mL)
  <0.005% water (100 mL pkg)
refractive index   n20/D 1.407(lit.)
bp   65-67 °C(lit.)
mp   −108 °C(lit.)
solubility   H2O: soluble
density   0.889 g/mL at 25 °C(lit.)

Description

Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Packaging

1, 6×1, 2, 4×2 L in Sure/Seal™

18 L in Pure-Pac™ 1

50, 200 L in Pure-Pac™ 2

View returnable container options.

100, 12×100 mL in Sure/Seal™

208 L in steel drum

Application

Dry tetrahydrofuran (THF) has been used in the synthesis of dichloro{bis[1,1′,1′′-(phosphinetriyl)tripiperidine]}palladium [(P(NC5H10)3)2Pd(Cl)2], which is widely used in the Heck reaction as a catalyst. It has been employed in the reaction medium of the Heck cross-coupling reaction of various aryl bromides and olefins.

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Supplemental Hazard Statements 
May form explosive peroxides.
RIDADR 
UN 2056 3 / PGII
WGK Germany 
1
RTECS 
LU5950000
Flash Point(F) 
1.4 °F
Flash Point(C) 
-17 °C

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis. These documents are located on the product detail page under Useful Links & Tools. Click on the following link to search for a Certificate of Analysis. Please click the following link to see the details on our Product Dating Information.
How do I get lot-specific information or a Certificate of Analysis?
A Certificate of Analysis is available by lot number and can be obtained through our Advanced Search Option: http://www.sigmaaldrich.com/catalog/AdvancedSearchPage.do
Who do I contact about larger solvent volume needs?
Email us at labessentials@sial.com or visit Sigma-Aldrich Fine Chemicals for development and manufacturing-scale inquiries: safcglobal@sial.com
How do I know what packaging options are available for a solvent?
The Solvent Center gives you the ability to review all the specifications associated with our solvent packaging. This includes physical dimensions, closure types, dispensing methods, UN/DOT Rating as well as solvent compatibility. Visit the Solvent Center at: http://www.sigmaaldrich.com/chemistry/solvents.html
Who do I contact if I need a solvent blend, which you do not carry?
Email us at http://labessentials@sial.com. For a complete listing of all our Solvent blends, visit the Solvent Center: http://www.sigmaaldrich.com/chemistry/solvents.html
The dispensing of solvents provides some challenges due to the number of container options available. What dispensing options are available for each container?
The Sigma-Aldrich Solvent Center provides numerous dispensing options for each container type. For a complete listing of all our dispensing options, visit the Solvent Center: http://www.sigmaaldrich.com/chemistry/solvents.html
Which solvent grade should I be using for my application?
Sigma-Aldrich Solvent Applications Table gives a guideline to common applications and the appropriate solvent grades.  Visit:  http://www.sigmaaldrich.com/solvents
What are the options for drying solvents?  
Sigma-Aldrich offers a full range of high-purity solvents with extremely low water levels specifically manufactured for moisture sensitive Organic and Biotech applications.  Sigma-Aldrich also carries various drying agents such as molecular sieves, which are typically compatible with organic solvents.
What apparatus do you recommend for HPLC solvent filtration?
The Sigma-Aldrich Vacuum Filtration Assembly gives you all the components you need including: funnel top, fritted glass funnel support, filtration flask, aluminum clamp, and silicone stopper.  The Acrodisc Syringe Filters offer high quality filtration for analytical samples, certified for HPLC to ensure low extractable and available in a broad range of membranes to meet sample compatibility requirements.
Can you recommend a Solvent Extractor for organics from aqueous solution?
Solvent extractors are often used for the quantitative extraction of organics from aqueous solutions and separations in immunoassays. The MIXXOR system has been applied successfully in many laboratory solvent extraction operations and is ideal for the rapid screening of alternative solvents for specific extraction problems.
Why do peroxides form in certain solvents and how do I test for it?
A significant number of laboratory solvents can undergo autoxidation under normal storage conditions to form unstable and potentially dangerous peroxide by-products. Molecular structure is the primary factor relating to a material’s potential for hazardous peroxide formation.  It is important to understand the stability of materials in use and if unclear, consult Sigma-Aldrich Technical Support, techserv@sial.com or visit the Peroxide-forming Solvents web page by clicking on the following link: http://www.sigmaaldrich.com/Area_of_Interest/Research_Essentials/Solvents/Key_Resources/Peroxide_Formation.html
What are some of the preservatives used in the most common ethers and chlorinated solvents and why are they added?
Certain solvents will degrade over time requiring special handling and storage considerations. In addition, the products of certain degradation processes pose a potential safety risk if present at sufficiently high levels. For these types of materials, small amounts of stabilizing chemicals are added to slow down or stop material degradation.
How do I find price and availability?
There are several ways to find pricing and availability for our products.  Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers. 
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS. To access the shipping information for this material, use the link on the product detail page for the product, or search here. 
My question is not addressed here, how can I contact Technical Service for assistance?
Use the option to the right to "Ask a Question" by email of a Technical Service Scientist.
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Protocols & Articles

Articles

Complex Hydrides: A New Category of Solid-state Lithium Fast-ion Conductors

Research and development of solid-state lithium fast-ion conductors is crucial because they can be potentially used as solid electrolytes in all-solid-state batteries, which may solve the safety and ...
Motoaki Matsuo,1 Hiroyuki Oguchi,1,2 Hideki Maekawa,2 Hitoshi Takamura,2Shin-ichi Orimo,1*
Material Matters Volume 5 Article 4
Keywords: Calorimetry, Deposition, Diffraction, Diffusion, Melting, Nuclear magnetic resonance spectroscopy, Raman spectroscopy, Search, Spectra, Spectroscopy, Substitutions, Support, X-Ray diffraction, transformation

Electrolyte Reagents for Lithium-Ion Batteries

Introduction Battery grade electrolytes Solvents and additives Preparation of customized battery grade electrolyte solutions Materials References
Dr. Koji Abe
Advanced Energy Materials R&D Center, Chemicals Company, UBE Industries, Ltd.
Keywords: Acid value, Industries, Solvents

Related Content

Agriculture | Crop Protection Workflow

Pesticides are an essential component in modern agriculture and enable growers to fully realize the yield potential of their seeds. From compound discovery to active ingredient development, our chemi...
Keywords: Agriculture, Pesticides

Properties of Solvents Table

a. Gant, R., LC/GC 10(7), 515 (1992) 1. At 20 °C 2. At 20 °C +/- 5 °C relative to water at 4 °C 3. At 10mmHg pressure 4. At l=589.32nm
Keywords: Gas chromatography, High performance liquid chromatography

Peer-Reviewed Papers
15

References

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