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Calcium ionophore III

Selectophore, function tested

Synonym: Antibiotic A 23187, Calcium Ionophore A23187, Calimycin

  • CAS Number 52665-69-7

  • Empirical Formula (Hill Notation) C29H37N3O6

  • Molecular Weight 523.62

  •  Beilstein Registry Number 1096801

  •  EC Number 258-084-1

  •  MDL number MFCD00151202

  •  PubChem Substance ID 329752113

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Properties

Related Categories A - K, Analytical/Chromatography, Antibacterial, Antibiotics, Antibiotics A to Z,
grade   Selectophore
InChI Key   HIYAVKIYRIFSCZ-CYEMHPAKSA-N
quality   function tested
Mode of action   cell membrane | interferes
antibiotic activity spectrum   Gram-positive bacteria
  fungi
storage temp.   2-8°C

Description

Application

Ionophore highly selective for Ca2+. Potentiates responses to NMDA but not quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase.

CA was used in elucidating the mechanisms underlying the positive and inotropic and chronotropic ability of CA on isolated superfused guinea pig atria. It may also be used to stimulate and measure the erythrocyte Ca2+ dependent K+ channels as the K+ efflux.

Calcium ionophore III may be used in ionophore-based calcium selective conductometric microsensors for the detection of calcium ions in aqueous solutions. In NIH3T3 and rat1-fibroblast cell cultures, calcium ionophore III along with thapsigargin has been reported to increase the hepatic clock gene Per1 expression in the initial period of treatment.

Other Notes

Preparation of an optical chemical sensor for Ca2+ and Mg2+

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

General description

Calcium ionophore III (Calimycin;CA) is a divalent cation ionophore. It has ability to transport Ca2+ ions across membranes along a concentration gradient.

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Legal Information

Selectophore is a trademark of Sigma-Aldrich Chemie GmbH

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
DM4676000
Protocols & Articles
Peer-Reviewed Papers
15

References

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