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221198 Sigma-Aldrich

Formamide

ACS reagent, ≥99.5%

Synonym: Amide C1, Formic amide

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Properties

Related Categories ACS Grade, ACS Grade Solvents, ACS and Reagent Grade Solvents, Acids and Bases, Amber Glass Bottles,
Quality Level   200
grade   ACS reagent
vapor density   1.55 (vs air)
vapor pressure   0.08 mmHg ( 20 °C)
  30 mmHg ( 129 °C)
assay   ≥99.5%
autoignition temp.   932 °F
color   APHA: ≤10
refractive index   n20/D 1.447 (lit.)
bp   210 °C (lit.)
mp   2-3 °C (lit.)
transition temp   freezing point 2.0-3.0 °C
density   1.134 g/mL at 25 °C (lit.)
SMILES string   NC=O
InChI   1S/CH3NO/c2-1-3/h1H,(H2,2,3)
InChI key   ZHNUHDYFZUAESO-UHFFFAOYSA-N

Description

Application

The addition of formamide may enhance the specificity and efficiency of amplification of PCR (polymerase chain reaction). It may be used as an ammonia equivalent for the palladium-catalyzed aminocarbonylation of 1-bromo-3-trifluoromethylbenzene to form 3-(trifluoromethyl)benzamide.

Formamide destabilizes nucleic acid duplexes and may be used, typically, at a concentration of 50%, in hybridization protocols requiring lower hybridization temperatures.

Packaging

1, 4×4 L in glass bottle

100 mL in glass bottle

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
Target organs 
Blood
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
RTECS 
LQ0525000
Flash Point(F) 
347.0 °F
Flash Point(C) 
175 °C

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Meet Synthia - Retrosynthesis Sofware
Protocols & Articles

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Peer-Reviewed Papers
15

References

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