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25107 Sigma-Aldrich

Potassium citrate tribasic monohydrate

meets analytical specification of Ph. Eur., BP, FCC, E332, 99-100.5% (calc with ref. to anhyd. subst.)

Synonym: Citric acid tripotassium salt, Tripotassium citrate

  • CAS Number 6100-05-6

  • Linear Formula HOC(COOK)(CH2COOK)2 · H2O

  • Molecular Weight 324.41

  •  Beilstein/REAXYS Number 3924344

  •  EC Number 231-905-0

  •  MDL number MFCD00150442

  •  PubChem Substance ID 57648111

  •  NACRES NA.21



Related Categories Analytical/Chromatography, Biochemicals and Reagents, Biological Buffers, Pharmacopoeia, Pharmacopoeia A-Z,
Quality Level   200
assay   99-100.5% (calc with ref. to anhyd. subst.)
form   powder or crystals
quality   meets analytical specification of Ph. Eur., BP, FCC, E332
impurities   ≤0.0005% heavy metals (as Pb)
  4-6% water (Karl Fischer)
loss   3-6 loss on drying, 180°C
pH   7-9 (20 °C, 5%)
mp   275 °C (dec.) (lit.)
solubility   glycerol: soluble 1 gm in 2.5 ml
  water: soluble 1 gm in 0.65 ml
  alcohol: insoluble
anion traces   chloride (Cl-): ≤30 mg/kg
  oxalate (as oxalic acid): ≤100 mg/kg
  sulfate (SO42-): ≤50 mg/kg
cation traces   As: ≤1 mg/kg
  Cu: ≤10 mg/kg
  Fe: ≤10 mg/kg
  Hg: ≤1 mg/kg
  Na: ≤3000 mg/kg
  Pb: ≤1 mg/kg
  Zn: ≤10 mg/kg
suitability   in accordance for appearance of solution
  passes test for reaction against H2SO4
Featured Industry   Pharmaceutical (small molecule)
SMILES string   O.[K+].[K+].[K+].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O
InChI   1S/C6H8O7.3K.H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;;1H2/q;3*+1;/p-3



Potassium citrate tribasic monohydrate has been used for preparing citrate-supplemented water for feeding the Car5A, Car5B, and DKO breeding pairs of mice. Citrate supplementation enhances the perinatal death in mice. It is a citrate-based salt used as a phase constituent for characterizing ionic-liquid-based aqueous biphasic systems (ABS) and as a buffering agent.

Biochem/physiol Actions

Potassium citrate tribasic monohydrate is the potassium salt of citric acid. It enhances the bone density hence used in the treatment of osteoporosis. Additionally, it neutralizes the protein-induced metabolic acidosis.

Safety & Documentation

Safety Information

Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Protocols & Articles

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