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271012 Sigma-Aldrich

N,N-Dimethylacetamide

anhydrous, 99.8%

Synonym: DMAc

  • CAS Number 127-19-5

  • Linear Formula CH3CON(CH3)2

  • Molecular Weight 87.12

  •  Beilstein/REAXYS Number 1737614

  •  EC Number 204-826-4

  •  MDL number MFCD00008686

  •  PubChem Substance ID 57648218

  •  NACRES NA.21

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Properties

Related Categories Anhydrous, Anhydrous Solvents, Returnable Containers, Solvent Bottles, Solvent Packaging Options,
Quality Level   200
grade   anhydrous
vapor density   3 (vs air)
vapor pressure   2 mmHg ( 25 °C)
  4 mmHg ( 38 °C)
assay   99.8%
form   liquid
autoignition temp.   914 °F
expl. lim.   1.8 %, 100 °F
  11.5 %, 160 °F
impurities   <0.005% water
evapn. residue   <0.001%
refractive index   n20/D 1.437 (lit.)
pH   4 (20 °C, 200 g/L)
bp   164.5-166 °C (lit.)
mp   −20 °C (lit.)
density   0.937 g/mL at 25 °C (lit.)
SMILES string   CN(C)C(C)=O
InChI   1S/C4H9NO/c1-4(6)5(2)3/h1-3H3
InChI key   FXHOOIRPVKKKFG-UHFFFAOYSA-N

Description

Application

N,N-Dimethylacetamide may be used as a solvent in the following processes:
• Palladium (II) acetate-butyldi-1-adamantylphosphine catalyzed arylation of 2-isobutylthiazole with chlorobenzene to form 5-phenyl-2-isobutylthiazole.
• Synthesis of β-, γ-, and δ-metallo ester intermediates that can react with acid chlorides to form γ-, δ-, and ε-keto esters.
• Synthesis of (R)-(-)-methyl 1,1′-binaphthyl-2,2′-diylphosphate that can be used as a precursor for preparing (R)-(+)-1,1′-binaphthalene-2,2′-diol.

Packaging

1, 6×1, 2, 4×2 L in Sure/Seal™

View returnable container options.

100, 12×100, 250 mL in Sure/Seal™

200 L in Pure-Pac™ 1

Other Notes

The article number 271012-4X2L will be discontinued. Please order the single bottle 271012-2L which is physically identical with the same exact specifications.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
WGK Germany 
WGK 2
RTECS 
AB7700000
Flash Point(F) 
147.2 °F - closed cup
Flash Point(C) 
64 °C - closed cup

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Development of Pd/C-Catalyzed Cyanation of Aryl Halides

An orthogonal set of catalyst systems has been developed for the Suzuki?Miyaura coupling of 3,3-disubstituted and 3-monosubstituted allylboronates with (hetero)aryl halides. These methods allow for t...

Pressure-Temperature Calculator for Solvents

*Calculations provide estimated results based on Antoine's Coefficients and their associated temperature range values. Antoine's Coefficients were obtained from the National Institute of Standards an...

Peer-Reviewed Papers
15

References

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