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27285 Sigma-Aldrich

Ethylenediaminetetraacetic acid disodium salt dihydrate

meets analytical specification of Ph. Eur., BP, USP, FCC, 99.0-101.0%

Synonym: Disodium ethylenediaminetetraacetate dihydrate, EDTA disodium salt, EDTA-Na2, Edathamil, Edetate disodium salt dihydrate, Sequestrene Na2

  • CAS Number 6381-92-6

  • Empirical Formula (Hill Notation) C10H14N2Na2O8 · 2H2O

  • Molecular Weight 372.24

  •  Beilstein/REAXYS Number 3900609

  •  EC Number 205-358-3

  •  PubChem Substance ID 24856480

  •  NACRES NA.77

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Properties

Related Categories Analytical/Chromatography, Core Bioreagents, Enzyme Inhibitors, Essential Chemicals, Ethylenediaminetetraacetic acid (EDTA) and EDTA Solutions,
Agency/Method   tested according to BP
  tested according to Ph Eur
  tested according to USP
Quality Level   200
reg. compliance   tested according to FCC
assay   99.0-101.0%
quality   meets analytical specification of Ph. Eur., BP, USP, FCC
impurities   residual solvents, complies
  ≤0.001% cyanide (CN)
  ≤0.001% heavy metals (as Pb)
  ≤0.1% nitrilotriacetic acid (HPLC) (HPLC)
loss   8.7-11.4% loss on drying, 200 °C, 3 h
pH   4-5 (20 °C, 5%)
mp   248 °C (dec.) (lit.)
solubility   water: soluble 100 g/L at 20 °C
anion traces   chloride (Cl-): ≤100 mg/kg
  sulfate (SO42-): ≤500 mg/kg
cation traces   As: ≤1 mg/kg
  Ca:, in accordance
  Fe: ≤10 mg/kg
  Pb: ≤10 mg/kg
Featured Industry   Pharmaceutical (small molecule)
SMILES string   O.O.O.O.[Na+].[Na+].[Na+].[Na+].OC(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC(O)=O.OC(=O)CN(CCN(CC(O)=O)CC([O-])=O)CC([O-])=O
InChI   1S/C10H16N2O8.2Na.2H2O/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;2*1H2/q;2*+1;;/p-2
InChI key   OVBJJZOQPCKUOR-UHFFFAOYSA-L

Description

Application

Ethylenediaminetetraacetic acid disodium salt dihydrate has been used along with Na2HPO4 and citric acid for preparing Na2EDTA-McIlvaine buffer. Aqueous solution of Ethylenediaminetetraacetic acid disodium salt dihydrate has also been used for photocatalytic hydrogen production

Chelator of divalent cations. Inhibits enzymes, such as metalloproteases, that require divalent cations for activity.

Biochem/physiol Actions

Ethylenediaminetetraacetic acid disodium salt dihydrate is a widely used chelator of divalent cations like Ca+2 and inhibits metal ion-dependent proteases such as calcium-dependent cysteine proteases. EDTA also acts as a chelator of the zinc ion in the active site of metalloproteases; thus it inhibits metalloproteases that requires zinc for activity. Additionally, EDTA prevents platelet aggregation and is a preferred anticoagulant for platelet counts.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
Target organs 
Respiratory Tract
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
RTECS 
AH4410000
Flash Point(F) 
No data available
Flash Point(C) 
No data available

Documents

Certificate of Analysis (COA)

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Single- & multi-channel pipettes from BRAND
Protocols & Articles
Peer-Reviewed Papers
15

References

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