296082 Sigma-Aldrich

Diethyl ether

contains 1 ppm BHT as inhibitor, anhydrous, ≥99.7%

Synonym: DEE, Ether, Ethyl ether

  • CAS Number 60-29-7

  • Linear Formula (CH3CH2)2O

  • Molecular Weight 74.12

  •  Beilstein Registry Number 1696894

  •  EC Number 200-467-2

  •  MDL number MFCD00011646

  •  PubChem Substance ID 57648383



Related Categories Anhydrous, Anhydrous Solvents, Diethyl Ether, Returnable Containers, Solvent by Type,
grade   anhydrous
vapor density   2.6 (vs air)
vapor pressure   28.66 psi ( 55 °C)
  8.56 psi ( 20 °C)
assay   ≥99.7%
autoignition temp.   320 °F
contains   1 ppm BHT as inhibitor
expl. lim.   36.5 %
impurities   <0.003% water
  <0.005% water (100 mL pkg)
evapn. residue   <0.0003%
color   colorless
refractive index   n20/D 1.3530(lit.)
bp   34.6 °C(lit.)
  34.6 °C
mp   −116 °C(lit.)
density   0.706 g/mL at 25 °C(lit.)



1, 6×1 L in Sure/Seal™

18 L in Pure-Pac™ 1

View returnable container options.

100, 12×100 mL in Sure/Seal™

20 L in Pure-Pac™ 2


Diethyl ether has been used as a solvent for the preparation of 3-formyl-2,2,5,5-tetramethyl-1-oxy-pyrroline from 3-(N-methoxy-N-methylcarbamoyl)-2,2,5,5-tetramethyl-1-oxy-pyrroline using DIBAL.

General description

Diethyl ether is a highly volatile and flammable organic solvent. On storing for a long time, DEE can form organic peroxides, which can be suppressed by adding butylated hydroxytoluene (BHT) as a stabilizer. BHT scavenges the free radicals required for the peroxide formation.

Safety & Documentation

Safety Information

Signal word 
Hazard statements 
Precautionary statements 
Supplemental Hazard Statements 
May form explosive peroxides., Repeated exposure may cause skin dryness or cracking.
UN1155 - class 3 - PG 1 - Diethyl ether
WGK Germany 
Flash Point(F) 
-40 °F
Flash Point(C) 
-40 °C


Certificate of Analysis

Certificate of Origin

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Protocols & Articles


A New Biarylphosphine Ligand for the Pd-Catalyzed Synthesis of Diaryl Ethers under Mild Conditions

An efficient, general palladium catalyst for C-O bond-forming reactions of secondary and primary alcohols with a range of aryl halides has been developed using the ligand�1. Heteroaryl halides, and f...
Keywords: Chromatography, Flash chromatography, Ligands

A New Palladium Precatalyst Allows for the Fast Suzuki-Miyaura Coupling Reactions of Unstable Polyfluorophenyl and 2-Heteroaryl Boronic Acids

A method for the Pd-catalyzed coupling of 2-aminothiazole derivatives with aryl bromides and triflates is described. Significantly, for this class of nucleophiles, the coupling exhibits a broad subst...
Keywords: Catalysis, Chromatography

Copper-Free Sonogashira Coupling of Cyclopropyl Iodides with Terminal Alkynes

An efficient palladium-catalyzed cyanation of aryl chlorides is established. In the presence of a highly effective Pd/CM-phos catalyst, cyanation of aryl chlorides proceeds at 71 �C in general, which...
Keywords: Catalysis, Chromatography, Column chromatography, Gas chromatography, Ligands, Nuclear magnetic resonance spectroscopy

Design and preparation of new palladium precatalysts for C-C and C-N cross-coupling reactions

Good to excellent yields�of aryl trifluoromethyl sulfides, which are an important class of compounds in both the pharmaceutical and agrochemical areas, can be achieved under mild conditions by the Pd...
Keywords: Agrochemicals, Catalysis, Pharmaceutical

Palladium/Tris(tert-butyl)phosphine-Catalyzed Suzuki Cross- Couplings in the Presence of Water

The Suzuki reaction is an exceptionally useful cross-coupling process that has been widely applied in synthetic chemistry, and boronic acids are, by far, the most commonly employed coupling partner. ...
Keywords: Chromatography, Column chromatography, Cross couplings, Eliminations, Oxidative additions, Suzuki reactions

Pd-PEPPSI-IPent: An Active, Sterically Demanding Cross-Coupling Catalyst and Its Application in the Synthesis of Tetra-Ortho- Substituted Biaryls-

The halogenated 1H-1,2,4-triazole glycosides 6-11 were synthesized by BF3-activated glycosylation of 3(5)-chloro-1,2,4- triazole (2), 3,5-dichloro-1,2,4-triazole (3), 3,5-dibromo-1,2,4-triazole (4), ...
Keywords: Arylations, Catalysis, Coupling reactions, Cross couplings, Glycosylations, Purification, Separation

Pressure-Temperature Calculator for Solvents

*Calculations provide estimated results based on Antoine's Coefficients and their associated temperature range values. Antoine's Coefficients were obtained from the National Institute of Standards an...

The First Applications of Carbene Ligands in Cross-Couplings of Alkyl Electrophiles: Sonogashira Reactions of Unactivated Alkyl Bromides and Iodides

The synthesis of ?,?-alkynyl esters and amides using air-stable potassium alkynyltrifluoroborates as nucleophilic partners in a mild Suzuki-Miyaura cross-coupling reaction has been achieved. Propargy...
Keywords: Chromatography, Column chromatography, Coupling reactions, Cross couplings

The Palladium-Catalyzed Trifluoromethylation of Aryl Chlorides

A series of N-heterocyclic carbene catalysts (see picture) were prepared and evaluated in the Suzuki-Miyaura reaction. A variety of sterically encumbered tetra-ortho-substituted biaryl products were ...
Keywords: Chromatography, Flash chromatography

Related Content

Pressure-Temperature Nomograph Interactive Tool

The Pressure-Temperature Nomograph tool is an application of the Clausius-Clapeyron Equation, which assumes the heat of vaporization is a constant over a pressure range. Antoine´s Equation gets aroun...
Keywords: Evaporation, Vaporization

Properties of Solvents Table

a. Gant, R., LC/GC 10 (7), 515 (1992) 1. At 20 °C 2. At 20 °C +/- 5 °C relative to water at 4 °C 3. At 10 mmHg pressure 4. At l=589.32 nm
Keywords: Gas chromatography, High performance liquid chromatography

Peer-Reviewed Papers


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