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31591 Supelco

Ampicillin trihydrate

VETRANAL, analytical standard

Synonym: D-(−)-α-Aminobenzylpenicillin

  • CAS Number 7177-48-2

  • Empirical Formula (Hill Notation) C16H19N3O4S · 3H2O

  • Molecular Weight 403.45

  •  Beilstein/REAXYS Number 5399534

  •  EC Number 200-709-7

  •  MDL number MFCD00072036

  •  PubChem Substance ID 329753836

  •  NACRES NA.24

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Properties

Related Categories Additional Standards, Analytical Standards, Analytical/Chromatography, Antibiotics Standards, Bactericidal,
Quality Level   100
grade   analytical standard
InChI Key   RXDALBZNGVATNY-CWLIKTDRSA-N
product line   VETRANAL
form   neat
shelf life   limited shelf life, expiry date on the label
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
color   white to off-white
mp   198-200 °C (dec.) (lit.)
Featured Industry   Pharmaceutical (small molecule)
Mode of action   cell wall synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
format   neat
storage temp.   2-8°C

Description

General description

Ampicillin trihydrate is a stable hydrated form of ampicillin.

Chemical structure: ß-lactam

Application

Ampicillin trihydrate has been used as reference standard for determining the residual solvents and its effect on ampicillin trihydrate crystal structure using GC, X-ray powder diffraction (XRPD) and Fourier transform infrared spectroscopy (FT-IR).

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

A β-lactam antibiotic with an amino group side chain attached to the penicillin structure. Penicillin derivative that inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidases on the inner surface of the bacterial cell membrane. Bactericidal only to growing Escherichia coli . Mode of resistance: Cleavage of β-lactam ring of ampicillin by β-lactamase. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.

Packaging

250 mg

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Legal Information

VETRANAL is a trademark of Sigma-Aldrich Chemie GmbH

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
XH8425000

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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