322415 Sigma-Aldrich


anhydrous, 99.8%

Synonym: Methyl alcohol



Related Categories Allium cepa (Onion), Anhydrous, Anhydrous Solvents, Cell Biology, Citrus aurantium (Seville orange),
Quality Level   100
grade   anhydrous
vapor density   1.11 (vs air)
vapor pressure   410 mmHg ( 50 °C)
  97.68 mmHg ( 20 °C)
assay   99.8%
form   liquid
autoignition temp.   725 °F
expl. lim.   36 %
application(s)   tissue processing: suitable
impurities   <0.002% water
  <0.005% water (100 mL pkg)
evapn. residue   <0.0003%
refractive index   n20/D 1.329 (lit.)
bp   64.7 °C (lit.)
mp   −98 °C (lit.)
density   0.791 g/mL at 25 °C (lit.)
storage temp.   room temp
SMILES string   CO
InChI   1S/CH4O/c1-2/h2H,1H3


General description

Methanol is an industrial organic solvent commonly used in organic synthesis. It is being considered as a potential hydrogen source in fuel cell technology due to its high H/C ratio, low propensity for soot generation, relatively low reforming temperature and its liquid state at room temperature. The olefins (ethylene or propylene) formed from methanol via MTO (methanol-to-olefins) process, can be an alternative to oil and gas to produce hydrocarbon fuels.


Methanol has been used for fixing the tissues during preparation of thin giemsa stained blood smears. It has been used in the purification step during the synthesis of pyocyanin, a toxic compound found in Pseudomonas aeruginosa.

Methanol has been used in following applications:
• Used for the synthesis and purification of pyocyanin, spectrophotometric estimation of pyocyanin concentration, and the calculation of pyocyanin molar concentration using spectrophotometer absorption data.
• Used as a component of staining solution used in karyotyping.
• Used as a component of staining solution to stain cell colonies in colony formation assay.


1, 6×1, 2, 4×2 L in Sure/Seal™

18 L in Pure-Pac™ 1

20 L in Pure-Pac™ 2

View returnable container options.

100, 12×100 mL in Sure/Seal™

200 L in Pure-Pac™ 1

Other Notes

Pure-Pac® II containers require the Micromatic MacroValve coupler for dispensing solvents, Z560723.

Legal Information

Pure-Pac is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Signal word 
Hazard statements 
Target organs 
UN1230 - class 3 - PG 2 - Methanol
WGK Germany 
Flash Point(F) 
49.5 °F - closed cup
Flash Point(C) 
9.7 °C - closed cup


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles


Cross Coupling Reactions of Chiral Secondary Organoboronic Esters With Retention of Configuration-

We describe a systematic study of the scope and relationship between ligand structure and activity for a highly efficient and selective class of catalysts containing sterically hindered chelating alk...
Keywords: Aminations, Gas chromatography, Ligands

Inorganic Graphene Analogues

Nanomaterials have steadily established their presence in day to-day life owing to their many-fold efficiency over bulk materials and due to the advancements in processing that have rendered them rem...
Keywords: Adsorption, Asymmetric synthesis, Centrifugation, Chemical vapor deposition, Deposition, Electronics, Environmental, Filtration, Homogenization, Metal organic frameworks, Nanomaterials, Nanotubes, Nucleic acid annealing, Oxidations, Positron Emission Tomography, Printed electronics, Semiconductor, Separation, Solar cells, Solvents, Spin coating

Mild and general palladium-catalyzed synthesis of methyl aryl ethers enabled by the use of a palladacycle precatalyst

A general method for the Pd-catalyzed coupling of methanol with (hetero)aryl halides is described. The reactions proceed under mild conditions with a wide range of aryl and heteroaryl halides to give...
Keywords: Catalysis, Chromatography, Column chromatography

Pressure-Temperature Calculator for Solvents

*Calculations provide estimated results based on Antoine's Coefficients and their associated temperature range values. Antoine's Coefficients were obtained from the National Institute of Standards an...

Peer-Reviewed Papers


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