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Cyclosporin A

VETRANAL, analytical standard

Synonym: Antibiotic S 7481F1, Cyclosporine

  • CAS Number 59865-13-3

  • Empirical Formula (Hill Notation) C62H111N11O12

  • Molecular Weight 1202.61

  •  Beilstein/REAXYS Number 3647785

  •  MDL number MFCD00274558

  •  PubChem Substance ID 329754203

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, Immunosuppressants, Pharmaceuticals, Illicit Drugs & Alcohol
grade   analytical standard
InChI Key   PMATZTZNYRCHOR-CGLBZJNRSA-N
product line   VETRANAL
form   neat
shelf life   limited shelf life, expiry date on the label
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
Featured Industry   Pharmaceutical (small molecule)
format   neat

Description

General description

Cyclosporin A (CsA) is a fungal metabolite, a cyclic undecapeptide. It has highly specific immunosuppressive effects with low myelotoxicity, thereby making it a valuable drug in human organ transplantation. Its immunosuppressive activity is based upon its ability to inhibit early steps of T-lymphocyte activation such as lymphokine gene transcription.

Cyclosporin A has been used to:
• Prevent rejection of kidney and liver transplants.
• In graft versus host disease.
• Treatment of autoimmune diseases.
• Treatment of Schistosomiasis.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.

Legal Information

VETRANAL is a trademark of Sigma-Aldrich Chemie GmbH

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
GZ4120000

Documents

Certificate of Analysis

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Protocols & Articles

Articles

LC/MS/MS Analysis of Immunosuppressant Drugs in Human Plasma on Ascentis® Express F5 after SPE Using HybridSPE®-Phospholipid

From our library of Articles, Sigma-Aldrich presents LC/MS/MS Analysis of Immunosuppressant Drugs in Human Plasma on Ascentis® Express F5 after SPE Using HybridSPE®-Phospholipid
Keywords: Chromatography, High performance liquid chromatography, Mass spectrometry, Sample preparations, Separation, Solid phase extractions, Solvents, Vitamins

LC/MS/MS Analysis of Immunosuppressant Drugs on apHera™ C18

From our library of Articles, Sigma-Aldrich presents LC/MS/MS Analysis of Immunosuppressant Drugs on apHera™ C18
Keywords: Chromatography, Clinical, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Solvents

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

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