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Meropenem trihydrate

VETRANAL, analytical standard

Synonym: (1R,5S,6S)-2-[(3S,5S)-5-(dimethylaminocarbonyl)pyrrolidin-3-ylthio]-6-[(R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylic acid trihydrate

  • CAS Number 119478-56-7

  • Empirical Formula (Hill Notation) C17H25N3O5S · 3H2O

  • Molecular Weight 437.51

  •  MDL number MFCD08600005

  •  PubChem Substance ID 329754224

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, Antibiotics Standards, Pharmaceuticals, Illicit Drugs & Alcohol
Quality Level   100
grade   analytical standard
InChI Key   CTUAQTBUVLKNDJ-OBZXMJSBSA-N
product line   VETRANAL
form   neat
shelf life   limited shelf life, expiry date on the label
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
Featured Industry   Pharmaceutical (small molecule)
format   neat
shipped in   wet ice
storage temp.   −20°C

Description

General description

Meropenem trihydrate (Meropenem) is a broad-spectrum carbapenem with antibacterial properties. It inhibits cell wall synthesis in both gram-negative and gram-positive bacteria.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Meropenem has been used as a reference standard in an experiment conducted to investigate the effects on in vivo efficacy caused due to chemical differences in three generic products of meropenem.

Meropenem penetrates cell walls and binds to penicillin-binding protein targets. It acts against aerobes and anaerobes including E. coli, Klebsiella, Clostridium, Enterococcus sp. It is a common cause of mild transient aminotransferase elevations and can rarely result in clinically apparent, cholestatic liver injury.

Meropenem trihydrate is an ultra-broad spectrum beta-lactam antibiotic active against both Gram-positive and Gram-negative bacteria.

Legal Information

VETRANAL is a trademark of Sigma-Aldrich Chemie GmbH

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

LC/MS Analysis of Meropenem in Plasma on Titan™ Silica 1.9 μm

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Meropenem in Plasma on Titan™ Silica 1.9 μm
Keywords: Antibiotics, Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Pharmaceutical, Precipitation, Sample preparations

UHPLC Analysis of Meropenem and Biapenem Antiobiotics on Ascentis® Express HILIC

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Meropenem and Biapenem Antiobiotics on Ascentis® Express HILIC
Keywords: High performance liquid chromatography, Pharmaceutical

UHPLC Analysis of Meropenem and Biapenem Antiobiotics on Ascentis® Express OH5

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Meropenem and Biapenem Antiobiotics on Ascentis® Express OH5
Keywords: Antibiotics, Chromatography, High performance liquid chromatography, Pharmaceutical

Peer-Reviewed Papers
15

References

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