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Voriconazole

VETRANAL®, analytical standard

Synonym: 2R,3S-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol, UK-109496

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, Antifungals, Pharmaceuticals, Illicit Drugs & Alcohol
Quality Level   100
grade   analytical standard
product line   VETRANAL®
form   neat
shelf life   limited shelf life, expiry date on the label
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
Featured Industry   Forensics and Toxicology
Pharmaceutical (small molecule)
format   neat
SMILES string   C[C@@H](c1ncncc1F)[C@](O)(Cn2cncn2)c3ccc(F)cc3F
InChI   1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1
InChI key   BCEHBSKCWLPMDN-MGPLVRAMSA-N

Description

General description

Voriconazole is a second-generation triazole, and is derived from fluconazole. It has a broad and enhanced antifungal spectrum as compared to other older triazoles. It is mostly well tolerated and is available in both oral and intravenous formulations.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

It has been used as one of the constituent of YPD (1% yeast extract, 2% peptone, 2% glucose) liquid media.

Voriconazole is an antifungal used to treat serious fungal infections. Voriconazole inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-α sterol demethylase resulting in a depletion of ergosterol in fungal cell membranes.

Voriconazole is an antifungal used to treat serious fungal infections. Voriconazole inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-a sterol demethylase resulting in a depletion of ergosterol in fungal cell membranes.

Legal Information

VETRANAL is a registered trademark of Sigma-Aldrich Chemie GmbH

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
WGK 3
RTECS 
UV9145000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

LC/MS Analysis of Antifungals on Ascentis® Express Biphenyl

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Antifungals on Ascentis® Express Biphenyl
Keywords: Antifungals, Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Pharmaceutical

LC/MS Analysis of Antifungals on Ascentis® Express Phenyl-Hexyl

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Antifungals on Ascentis® Express Phenyl-Hexyl
Keywords: Antifungals, Chromatography, High performance liquid chromatography, Mass spectrometry, Pharmaceutical

UHPLC Analysis of Antifungals on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Antifungals on Ascentis® Express C18
Keywords: Antifungals, Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Pharmaceutical, Solvents

UHPLC Analysis of Antifungals on Titan™ C18

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Antifungals on Titan™ C18
Keywords: Antifungals, Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Pharmaceutical, Solvents

Peer-Reviewed Papers
15

References

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