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33731 Sigma-Aldrich

Trichloroacetic acid

puriss. p.a., ACS reagent, ≥99.5%

Synonym: TCA

  • CAS Number 76-03-9

  • Linear Formula Cl3CCOOH

  • Molecular Weight 163.39

  •  Beilstein/REAXYS Number 970119

  •  EC Number 200-927-2

  •  MDL number MFCD00004177

  •  PubChem Substance ID 57648907

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Properties

Related Categories Acids, Acids & Bases, Analytical Reagents, Analytical Reagents for General Use, Analytical/Chromatography,
grade   ACS reagent
vapor density   <1 (vs air)
vapor pressure   1 mmHg ( 51 °C)
grade   puriss. p.a.
assay   ≥99.5%
impurities   ≤0.002% heavy metals (as Pb)
  ≤0.005% water insolubles
ign. residue   ≤0.01% (as SO4)
refractive index   n20/D 1.62 (lit.)
bp   196 °C (lit.)
mp   54-58 °C (lit.)
density   1.62 g/mL at 25 °C (lit.)
anion traces   chloride (Cl-): ≤10 mg/kg
  nitrate (NO3-): ≤20 mg/kg
  phosphate (PO43-): ≤5 mg/kg
  sulfate (SO42-): ≤100 mg/kg
cation traces   Cu: ≤5 mg/kg
  Fe: ≤10 mg/kg
suitability   complies for appearance of solution
SMILES string   OC(=O)C(Cl)(Cl)Cl
InChI   1S/C2HCl3O2/c3-2(4,5)1(6)7/h(H,6,7)
InChI key   YNJBWRMUSHSURL-UHFFFAOYSA-N

Description

General description

Trichloroacetic acid (TCA) is a chlorinated acetic acid. It is one of the major metabolite of trichloroethylene (TCE).

Application

Trichloroacetic acid may be used for the quantification of inorganic phosphorus in various biological samples (serum, urine and stool ash solutions). It may be used for the elimination of acid-soluble and lipid phosphorous during the quantitative estimation of deoxyribonucleic acid, ribonucleic acid and phosphoproteins in animal tissues. 10% trichloroacetic acid may be employed for the preparation of radioactive proteins.

Traditionally used to precipitate protein. Has been used to determine protein concentration by quantitative precipitation. Used as decalcifier and fixative in microscopy.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Target organs 
Respiratory system
RIDADR 
UN 1839 8 / PGII
WGK Germany 
WGK 2
RTECS 
AJ7875000

Documents

Certificate of Analysis (COA)

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Protocols & Articles

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