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Norfloxacin

VETRANAL, analytical standard

Synonym: 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid, 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-3-quinolinecarboxylic acid

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Properties

Related Categories 1694 Pharmaceuticals & Personal Care Products, Additional Standards, Analytical Standards, Analytical/Chromatography, Antibiotics Standards,
Quality Level   100
grade   analytical standard
InChI Key   OGJPXUAPXNRGGI-UHFFFAOYSA-N
product line   VETRANAL
form   neat
shelf life   limited shelf life, expiry date on the label
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
Agency/Method   EPA 1694
Featured Industry   Environmental
Pharmaceutical (small molecule)
format   neat
storage temp.   2-8°C

Description

General description

Norfloxacin is an antimicrobial drug, belonging to the class of fluoroquinolones (FQs), which shows broad-spectrum activity against a wide range of Gram-negative and Gram-positive organisms.

Application

Norfloxacin may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations, biological fluids and sewage using various chromatography techniques.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Norfloxacin blocks DNA replication by interfering with an ATP-induced structural transition of DNA complexed with DNA gyrase (topoisomerase).
Mode of action: inhibits bacterial DNA replication
Antimicrobial spectrum: Gram-negative bacteria; less effective against Gram-positive bacteria

Legal Information

VETRANAL is a trademark of Sigma-Aldrich Chemie GmbH

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
VB2005000

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

HPLC Analysis of Antibacterials/Antifungals on Ascentis® RP-Amide, Phosphate Mobile Phase

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Antibacterials/Antifungals on Ascentis® RP-Amide, Phosphate Mobile Phase
Keywords: Antibiotics, Antifungals, Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Fluoroquinolone Antibiotics on Ascentis® Phenyl

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Fluoroquinolone Antibiotics on Ascentis® Phenyl
Keywords: Antibiotics, Chromatography, High performance liquid chromatography, Mass spectrometry, Pharmaceutical

Peer-Reviewed Papers
15

References

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