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34012 Supelco

Fluoxetine hydrochloride

VETRANAL®, analytical standard

Synonym: (±)-N-Methyl-γ-[4-(trifluoromethyl)phenoxy]benzenepropanamine hydrochloride, LY-110,140 hydrochloride, Prozac®

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Properties

Related Categories Additional Standards, Analytical Standards, Analytical/Chromatography, Antidepressants, Chromatography,
Quality Level   100
grade   analytical standard
product line   VETRANAL®
form   neat
shelf life   limited shelf life, expiry date on the label
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
Featured Industry   Pharmaceutical (small molecule)
format   neat
SMILES string   CNCCC(C1=CC=CC=C1)OC2=CC=C(C(F)(F)F)C=C2.[H]Cl
InChI   1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H
InChI key   GIYXAJPCNFJEHY-UHFFFAOYSA-N

Description

General description

Fluoxetine hydrochloride is an antidepressant drug and a selective serotonin reuptake inhibitor, which is widely used for the treatment of major depressive disorders, obsessive-compulsive disorder and panic fits.

Application

Fluoxetine hydrochloride may be used as an analytical reference standard for the quantification of the analyte in biological fluids using various chromatography techniques.

Fluoxetine hydrochloride may be used as an antidepressant, since it can selectively inhibit the serotonin uptake in the brain. It may also be used in the management of a variety of psychiatric and metabolic derangements.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Selective serotonin reuptake inhibitor; antidepressant.

Legal Information

Sold under license from Eli Lilly and Company.

Prozac is a registered trademark of Eli Lilly and Co.

VETRANAL is a registered trademark of Sigma-Aldrich Chemie GmbH

Safety & Documentation

Safety Information

Signal word 
Danger
Hazard statements 
Target organs 
Central nervous system
Personal Protective Equipment 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
WGK 3
RTECS 
UI4050000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

GC Analysis of Fluoxetine Enantiomers (N-TFA Derivatives) on Astec® CHIRALDEX® B-DA

From our library of Articles, Sigma-Aldrich presents GC Analysis of Fluoxetine Enantiomers (N-TFA Derivatives) on Astec® CHIRALDEX® B-DA
Keywords: Chromatography, Clinical, Flame ionization detector, Forensic, Gas chromatography, Pharmaceutical, Purification

HPLC Analysis of Fluoxetine (Prozac®) and Norfluoxetine on Discovery® Zr-PS

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Fluoxetine (Prozac®) and Norfluoxetine on Discovery® Zr-PS
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Fluoxetine (Prozac®) on Discovery® Cyano

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Fluoxetine (Prozac®) on Discovery® Cyano
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Fluoxetine Enantiomers on Astec® CHIROBIOTIC® V2

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Fluoxetine Enantiomers on Astec® CHIROBIOTIC® V2
Keywords: Anti-depressants, Chromatography, Clinical, Forensic, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Fluoxetine Enantiomers on Narrowbore Astec® CHIROBIOTIC® V2

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Fluoxetine Enantiomers on Narrowbore Astec® CHIROBIOTIC® V2
Keywords: Anti-depressants, Chromatography, High performance liquid chromatography, Pharmaceutical

UHPLC-MS Analysis of Basic Drugs and Metabolites with Titan™ C18

From our library of Articles, Sigma-Aldrich presents UHPLC-MS Analysis of Basic Drugs and Metabolites with Titan™ C18
Keywords: Chromatography, Mass spectrometry, Metabolites

Peer-Reviewed Papers
15

References

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