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34089 Supelco

Fosfomycin sodium

VETRANAL, analytical standard

Synonym: (−)-(1R,2S)-(1,2-Epoxypropyl)phosphonic acid, Fosfomycin, Phosphomycin disodium salt, Phosphonomycin

  • CAS Number 26016-99-9

  • Empirical Formula (Hill Notation) C3H5Na2O4P

  • Molecular Weight 182.02

  •  Beilstein/REAXYS Number 4604425

  •  EC Number 247-409-2

  •  MDL number MFCD22741288

  •  PubChem Substance ID 329754806

  •  NACRES NA.24

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Properties

Related Categories Additional Standards, Analytical Standards, Analytical/Chromatography, Antibiotics Standards, Bacteriostatic,
Quality Level   100
grade   analytical standard
InChI Key   QZIQJIKUVJMTDG-JSTPYPERSA-L
product line   VETRANAL
form   neat
shelf life   limited shelf life, expiry date on the label
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
Featured Industry   Pharmaceutical (small molecule)
format   neat
storage temp.   2-8°C

Description

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Antibiotic that concentrates in kidney and bladder; reduces nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents. Fosfomycin is a phosphoenolpyruvate analog that irreversibly inhibits UDP-GlcNAc enolpyruvyl tranferase (MurA), an enzyme involved in bacterial cell wall biosynthesis. As a result, the production of N-acetylmuramic acid, an essential element of the peptidoglycan cell wall, is inhibited.

Legal Information

VETRANAL is a trademark of Sigma-Aldrich Chemie GmbH

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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