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35342 Supelco

2,5-Dimethyl-celecoxib

VETRANAL, analytical standard

Synonym: 2,5-Dimethylcelecoxib, 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, Opiates / Synthetic Analgesic Drug Standards, Pharmaceuticals, Illicit Drugs & Alcohol
grade   analytical standard
InChI Key   NTFOSUUWGCDXEF-UHFFFAOYSA-N
product line   VETRANAL
form   neat
shelf life   limited shelf life, expiry date on the label
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
Featured Industry   Pharmaceutical (small molecule)
format   neat
storage temp.   2-8°C

Description

General description

2,5-Dimethyl-celecoxib is a derivative of the anti-inflammatory drug, celecoxib.

Application

2,5-Dimethyl-celecoxib may be used as an internal standard for the determination of celecoxib in human plasma samples by liquid chromatography coupled to electrospray ionization and time of flight mass spectrometry (LC-ESI-TOF-MS).

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Celecoxib, and the inactive analog 2′,5′-dimethyl celecoxib both induce apoptosis in a many cancer cell lines by down-regulating the expression of survivin. This activiy is mediated via an AKT mediated pathway, and is unique to this class of cyclo-oxygenase inhibitors, as non-selective NSAIDs or other COX-2 specific inhibitors such as rofecoxib, do not effect survivin expression. Unlike celecoxib, 2′,5′-dimethyl celecoxib is devoid of any inhibitory activity against COX-2.

Legal Information

VETRANAL is a trademark of Sigma-Aldrich Chemie GmbH

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3

Documents

Certificate of Analysis

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Protocols & Articles
Peer-Reviewed Papers
15

References

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