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37019 Supelco

Atropine

analytical standard

Synonym: Hyoscyamine, Tropine tropate, endo-(±)-α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester

  • CAS Number 51-55-8

  • Empirical Formula (Hill Notation) C17H23NO3

  • Molecular Weight 289.37

  •  Beilstein/REAXYS Number 91260

  •  EC Number 200-104-8

  •  MDL number MFCD00022622

  •  PubChem Substance ID 329755584

  •  NACRES NA.24

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Properties

Related Categories Alkaloids / Nitrogen Containing Compounds, Analytical Standards, Analytical/Chromatography, Biotoxin and Mycotoxin Standards, Food and Cosmetic Component Standards,
Quality Level   100
grade   analytical standard
form   neat
shelf life   limited shelf life, expiry date on the label
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
Featured Industry   Cleaning Products
Cosmetics
Food and Beverages
Personal Care
format   neat
storage temp.   −20°C
SMILES string   CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3
InChI   1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?
InChI key   RKUNBYITZUJHSG-SPUOUPEWSA-N
Gene Information   human ... CHRM1(1128), CHRM2(1129), CHRM3(1131)

Description

General description

Atropine is an antimuscarinic drug, which is classified under the tropane alkaloid family of compounds.

Application

Atropine may be used as a reference standard for the determination of atropine in:
• Blood samples by liquid chromatography combined with electrospray ionization-triple quadrupole mass spectrometry (LC-ESI-MS/MS).
• Hair samples by ultra-high performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS) consisting of single-stage Orbitrap MS system with ESI interface.
• Oganic buckwheat (Fagopyron esculentum L.) products by UHPLC-MS/MS.
• Plant materials by liquid-liquid extraction and EXtrelut® column clean-up followed by analysis using gas chromatography (GC) coupled with flame ionization detector (FID) and MS.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Atropine may be used as a reference standard for the determination of atropine in:
• Blood samples by liquid chromatography combined with electrospray ionization-triple quadrupole mass spectrometry (LC-ESI-MS/MS).
• Hair samples by ultra-high performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS) consisting of single-stage Orbitrap MS system with ESI interface.
• Oganic buckwheat (Fagopyron esculentum L.) products by UHPLC-MS/MS.
• Plant materials by liquid-liquid extraction and EXtrelut® column clean-up followed by analysis using gas chromatography (GC) coupled with flame ionization detector (FID) and MS.

Biochem/physiol Actions

Competitive nonselective antagonist at central and peripheral muscarinic acetylcholine receptors.

Reconstitution

Dried down, 100μg/mL after reconstitution with 1 mL of water

Legal Information

Extrelut is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 1544PSN1 6.1 / PGII
WGK Germany 
WGK 3
RTECS 
CK0700000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

HPLC Analysis of Atropine Enantiomers on Astec® Cellulose DMP

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Atropine Enantiomers on Astec® Cellulose DMP
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

TLC Analysis of Expectorants on HPTLC Silica Gel 60 RP-18 WF254s

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Expectorants on HPTLC Silica Gel 60 RP-18 WF254s
Keywords: Chromatography, Pharmaceutical, Thin layer chromatography

Peer-Reviewed Papers
15

References

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