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390062 Sigma-Aldrich

Thiazole Orange

Dye content ~90 %

Synonym: 1-Methyl-4-[(3-methyl-2(3H)-benzothiazolylidene)methyl]quinolinium p-tosylate

  • CAS Number 107091-89-4

  • Empirical Formula (Hill Notation) C26H24N2O3S2

  • Molecular Weight 476.61

  •  MDL number MFCD00192499

  •  PubChem Substance ID 24864313

  •  NACRES NA.47

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Properties

Related Categories Cell Biology, Hematology and Histology, Stains & Dyes, A to Z, Stains and Dyes, T-U-V More...
Quality Level   200
form   powder
composition   Dye content, ~90%
application(s)   hematology: suitable
  histology: suitable
mp   270 °C (dec.) (lit.)
λmax   512 nm
Featured Industry   Diagnostic Assay Manufacturing
storage temp.   room temp
SMILES string   Cc1ccc(cc1)S([O-])(=O)=O.CN2C(\Sc3ccccc23)=C\c4cc[n+](C)c5ccccc45
InChI   1S/C19H17N2S.C7H8O3S/c1-20-12-11-14(15-7-3-4-8-16(15)20)13-19-21(2)17-9-5-6-10-18(17)22-19;1-6-2-4-7(5-3-6)11(8,9)10/h3-13H,1-2H3;2-5H,1H3,(H,8,9,10)/q+1;/p-1
InChI key   ACOJCCLIDPZYJC-UHFFFAOYSA-M

Description

General description

Thiazole Orange can be tethered with peptide nucleic acid for the detection of target nucleic acid in homogeneous solution. It is a dye with, both predicted physical characteristics and the biological staining characteristics of a good reticulocyte dye, hence it is considered as a dye for reticulocyte analysis. It has massive fluorescence enhancement and high quantum yield upon binding to nucleic acids, particularly RNA. It is non precipitating and can permeates through live cell membranes.

Application

Thiazole orange has been used for the staining and thereby quantification of reticulocytes.

Packaging

1 g in glass bottle

250 mg in glass bottle

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Target organs 
Respiratory system
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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