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α-Cyano-4-hydroxycinnamic acid

matrix substance for MALDI-MS, Ultra pure

Synonym: α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA

  • CAS Number 28166-41-8

  • Linear Formula HOC6H4CH=C(CN)CO2H

  • Molecular Weight 189.17

  •  Beilstein/REAXYS Number 3271427

  •  EC Number 248-879-1

  •  MDL number MFCD00004204

  •  PubChem Substance ID 329755873

  •  NACRES NA.21

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Properties

Related Categories Analytical Reagents, Analytical/Chromatography, Mass Spectrometry, Mass Spectrometry (MS), Matrices for MALDI Analysis,
Quality Level   100
grade   matrix substance for MALDI-MS
analyte chemical class(es)   glycans, peptides, proteins
mp   245-250 °C (lit.)
  245-250 °C
solubility   methanol: 10 mg/mL, clear
cation traces   Al: ≤1 mg/kg
  Ba: ≤1 mg/kg
  Ca: ≤1 mg/kg
  Cd: ≤1 mg/kg
  Co: ≤1 mg/kg
  Cr: ≤1 mg/kg
  Cu: ≤1 mg/kg
  Fe: ≤1 mg/kg
  K: ≤1 mg/kg
  Li: ≤1 mg/kg
  Mg: ≤1 mg/kg
  Mn: ≤1 mg/kg
  Na: ≤1 mg/kg
  Ni: ≤1 mg/kg
  Pb: ≤1 mg/kg
  Sr: ≤1 mg/kg
  Zn: ≤1 mg/kg
storage temp.   2-8°C
SMILES string   OC(=O)\C(=C\c1ccc(O)cc1)C#N
InChI   1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+
InChI key   AFVLVVWMAFSXCK-VMPITWQZSA-N

Description

General description

α-Cyano-4-hydroxycinnamic acid (α-CHCA) functions as matrix and helps in facilitating ionization of proteins and peptides in a matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometer.

Application

It was used as matrix in improving the detection of low concentration protein digests on MALDI-TOF.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Target organs 
Respiratory system
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Ultra-pure MALDI Matrices

One of the most important aspects of our ultra-pure MALDI matrix substances is their ability to dissolve rapidly and completely; a brief vortex mixing is typically sufficient. Actual performance of t...
Monika Baeumle, Alex Rueck
Analytix Volume 7 Article 5
Keywords: Crystallization, Digestions, High performance liquid chromatography, Mass spectrometry, Phase transitions, Proteomics, Sample preparations

Peer-Reviewed Papers
15

References

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