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410225 Sigma-Aldrich

Glycine

ACS reagent, ≥98.5%

Synonym: Aminoacetic acid, Aminoethanoic acid, Glycocoll

  • CAS Number 56-40-6

  • Linear Formula NH2CH2COOH

  • Molecular Weight 75.07

  •  Beilstein/REAXYS Number 635782

  •  EC Number 200-272-2

  •  MDL number MFCD00008131

  •  eCl@ss 32160406

  •  PubChem Substance ID 24865701

  •  NACRES NA.21

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Properties

Related Categories Amino Acids, Amino Acids & Derivatives, Chemical Biology, Chemical Synthesis, Core Bioreagents,
Quality Level   200
grade   ACS reagent
assay   ≥98.5%
form   crystals
  powder or granules
application(s)   peptide synthesis: suitable
impurities   H2SO4, passes test (darkened)
  Hydrolyzable subsances, passes test
ign. residue   ≤0.1%
pKa (25 °C)   (1) 2.35, (2) 9.60
  2.35
mp   240 °C (dec.) (lit.)
anion traces   chloride (Cl-): ≤0.005%
  sulfate (SO42-): ≤0.005%
cation traces   NH4+: ≤0.005%
  heavy metals (as Pb): ≤0.002%
SMILES string   NCC(O)=O
InChI   1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
InChI key   DHMQDGOQFOQNFH-UHFFFAOYSA-N
Gene Information   rat ... Grin2a(24409)

Description

Application

Glycine has been used in whole-cell patch clamp recording to measure inward NMDA (N-methyl-D-aspartate) currents. It has also been used as a model organic system in crystallography to demonstrate a novel acoustic nebulization platform.

Packaging

50, 250 g in poly bottle

Biochem/physiol Actions

Glycine is a non-essential amino acid. Influx of calcium through the cell membrane is mediated by glycine-gated channel. Glycine participates in the synthesis of porphyrins, purine and serine. It also serves as a competitive agonist for glutamate in binding to the NMDA (N-methyl-D-aspartate) receptors. Glycine synthesis might be increased in rapidly proliferating cancer cells, due to increased demand for the amino acid.

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
RTECS 
MB7600000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

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Peer-Reviewed Papers
15

References

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