EMAIL THIS PAGE TO A FRIEND
437557 Sigma-Aldrich

Acetonitrile

≥99.5%, ACS reagent

Synonym: ACN, Methyl cyanide

Purchase

Properties

Related Categories ACS Grade, ACS Grade Solvents, ACS and Reagent Grade Solvents, Acetonitrile and Acetonitrile Solutions, PVC Coated Bottles,
grade   ACS reagent
vapor density   1.41 (vs air)
vapor pressure   72.8 mmHg ( 20 °C)
InChI Key   WEVYAHXRMPXWCK-UHFFFAOYSA-N
assay   ≥99.5%
form   liquid
autoignition temp.   973 °F
expl. lim.   16 %
impurities   ≤0.3% water
  ≤0.6 μeq/g Titr. base
  ≤8 μeq/g Titr. acid
evapn. residue   ≤0.005%
color   APHA: ≤10
refractive index   n20/D 1.344 (lit.)
bp   81-82 °C (lit.)
mp   −48 °C (lit.)
solubility   water: soluble
density   0.786 g/mL at 25 °C (lit.)

Description

General description

Acetonitrile (MeCN) is widely employed as a solvent in various studies and has high dielectric constant (37.5). Various purification procedures to obtain different grades of acetonitrile for use in different studies (polarography, spectroscopy, etc.) have been reported by many researchers.

Acetonitrile (MeCN), an aliphatic nitrile, is a colorless liquid with a pleasant odor. It is widely used as a solvent and intermediate in organic syntheses. It is transparent to UV-visible light making it highly applicable in spectrophotometric and fluorimetric techniques. As MeCN has low viscosity, high elution strength and is highly miscible in water, it is utilized as a mobile phase component in many chromatographic techniques. It also plays a major role as an extractant medium in liquid-liquid extraction, solid-phase extraction or microextraction. Its infrared spectrum has been recorded. Synthesis of alkyl hydroperoxides in MeCN by alkane oxidation with hydrogen peroxide in the presence of iron complexes has been studied. The hydrogenation of MeCN to form ethylamine using Co–B amorphous alloy catalyst has been investigated.

Application

Acetonitrile (MeCN) may be used as solvent in the following processes:
• Determination of pKa values of organic superbases using isodensity polarization continuum model (IPCM).
• Preparation of 1,2-azidoalcohols and 1,2-azidoamines via cerium(III) chloride assisted ring opening of epoxides and aziridines by sodium azide.
• Synthesis of cyano-bearing indolinones by oxidative arylalkylation of olefins in the presence of palladium catalyst.
• To study the dynamics of intramolecular charge-transfer (ICT) reaction of 4-(dimethylamino)benzonitrile.

Acetonitrile may be employed as a solvent for the quantification of vitamin D metabolites, 25-hydroxyvitamin D2 [25(OH)D2] and D3 [25(OH)D3] by HPLC.

Packaging

4×4 L in PVC-coated bottle

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 1648 3 / PGII
WGK Germany 
2
RTECS 
AL7700000
Flash Point(F) 
35.6 °F
Flash Point(C) 
2 °C

Documents

Certificate of Analysis

???PDP_SDS_LOT_NUMBER_ERROR_MSG???

Dispensette™ S
Protocols & Articles

Articles

Pressure-Temperature Calculator for Solvents

*Calculations provide estimated results based on Antoine's Coefficients and their associated temperature range values. Antoine's Coefficients were obtained from the National Institute of Standards an...

Related Content

Pressure-Temperature Nomograph Interactive Tool

Use the interactive controls above to simplify calculations and improve the efficiency of your distillation or evaporation requirements.
Keywords: Evaporation, Vaporization

Properties of Solvents Table

The table below presents the physical characteristics of common solvents. Easily reference or compare solvent properties like boiling point, density, and refractive index all from one list.
Keywords: Gas chromatography, Green chemistry, High performance liquid chromatography, Melting, Solvents

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?