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437573 Sigma-Aldrich

N,N-Dimethylformamide

ACS reagent, ≥99.8%

Synonym: DMF, NSC 5356

  • CAS Number 68-12-2

  • Linear Formula HCON(CH3)2

  • Molecular Weight 73.09

  •  Beilstein/REAXYS Number 605365

  •  EC Number 200-679-5

  •  MDL number MFCD00003284

  •  PubChem Substance ID 24867382

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Properties

Related Categories ACS Grade, ACS Grade Solvents, ACS and Reagent Grade Solvents, Dimethylformamide (DMF), PVC Coated Bottles,
Quality Level   200
grade   ACS reagent
vapor density   2.5 (vs air)
vapor pressure   2.7 mmHg ( 20 °C)
assay   ≥99.8%
form   liquid
autoignition temp.   833 °F
expl. lim.   15.2 %
impurities   ≤0.0005 meq/g Titr. acid
  ≤0.003 meq/g Titr. base
  ≤0.15% water
evapn. residue   ≤0.005%
color   APHA: ≤15
refractive index   n20/D 1.430 (lit.)
bp   153 °C (lit.)
mp   −61 °C (lit.)
solubility   water: miscible
density   0.944 g/mL (lit.)
SMILES string   [H]C(=O)N(C)C
InChI   1S/C3H7NO/c1-4(2)3-5/h3H,1-2H3
InChI key   ZMXDDKWLCZADIW-UHFFFAOYSA-N

Description

General description

N,N-Dimethylformamide (DMF) is a polar organic solvent with a wide range of industrial applications. It is a precursor for numerous reactions such as formylation, aminocarbonylation, amination, amidation and cyanation. Along with phosphorus oxychloride, it forms Vilsmeier reagent used in the formylation of reactive aromatic and heteroaromatic substrates. Dielectric relaxation experiments on DMF have been conducted between 238.15K and 338.15K. The thermophysical properties of the molecular interactions between DMF and the ionic liquids, ammonium salts and imidazolium salts have been studied. The characteristics of solute-solvent interactions between ammonium nitrate and DMF have been investigated.

Application

N,N-Dimethylformamide (DMF) may be used in the following processes:
• As a solvent synthesis of gold nanoparticles.
• As a solvent in capillary electrophoresis.
• Regioselective synthesis of N,N-dimethylaminopyridzines by reacting with choropyridazines.
• Synthesis of urea-N,N-dimethylformamide, a 3:1 solvate with urea.

Solvent for many hydrophobic organic compounds.

Packaging

18 L in VerSA-Flow™

4×4 L in PVC-coated bottle

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2265 3 / PGIII
WGK Germany 
WGK 2
RTECS 
LQ2100000
Flash Point(F) 
136.4 °F - closed cup
Flash Point(C) 
58 °C - closed cup

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

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Peer-Reviewed Papers
15

References

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