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439126 Sigma-Aldrich

Acetone

for HPLC, ≥99.9%

  • Linear Formula CH3COCH3

  • Molecular Weight 58.08

  •  Beilstein/REAXYS Number 635680

  •  EC Number 200-662-2

  •  MDL number MFCD00008765

  •  PubChem Substance ID 57650186

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Properties

Related Categories Acetone, Analytical Reagents, Analytical/Chromatography, Chromatography Reagents & Solvents, HPLC,
Quality Level   100
grade   for HPLC
vapor density   2 (vs air)
vapor pressure   184 mmHg ( 20 °C)
assay   ≥99.9%
expl. lim.   13.2 %
impurities   ≤0.5% (water)
evapn. residue   <0.0002%
color   colorless
refractive index   n20/D 1.359 (lit.)
bp   56 °C/760 mmHg (lit.)
mp   −94 °C (lit.)
solubility   water: miscible
density   0.791 g/mL at 25 °C (lit.)
λ   H2O reference
UV absorption   λ: 330 nm Amax: 1.00
  λ: 340 nm Amax: 0.10
  λ: 350 nm Amax: 0.02
  λ: 400 nm Amax: 0.01
suitability   suitable (pesticide analysis)
SMILES string   CC(C)=O
InChI   1S/C3H6O/c1-3(2)4/h1-2H3
InChI key   CSCPPACGZOOCGX-UHFFFAOYSA-N

Description

General description

Acetone is a ketone. Mixtures of TiO2 (P25) with rare earth oxides (La2O3 or Y2O3) calcined at 700°C or 650°C has been reported to efficiently photocatalyze the oxidation of acetone. Its aldol condensation in vapor-phase has been investigated over MgO promoted with alkali (Li, Na, K and Cs) or alkaline earth (Ca, Sr and Ba) metal ions. It undergoes Aldol condensation in the presence of Mg-Al layered double hydroxides (LDH) as catalysts and Cl- and/or CO32- as compensating anions to afford diacetone alcohol and mesityl oxide. Enantioselective Aldol condensation of acetone with various isatins in the presence of dipeptides (catalyst) has been described.

Application

Acetone was used in the affinity purification of modified proteins using streptavidin beads for the mass spectrometric (MS) identification of poly(ADP-ribose) polymerases (PARP) substrate proteins.
It may be used in the following studies:
• NMR spectroscopic evaluation of glucose metabolism in biological samples (blood).
• Preparation of 13wt% amorphous poly (lactic acid) (PLA) solution, which was required for the preparation of electrospun PLA membranes.
• As a precursor for the synthesis of methyl isobutyl ketone (MIBK) in the presence of sulfonated graphene oxide-Pd/cordierite catalyst.
• Synthesis of (4-hydroxymethyl-2,2-dimethyl-1,3-dioxolane), a solketal from glycerol using supercritical fluids (SCF) technology.
It may be used in the synthesis of the following acetone hydrazones:
• 1-isopropylidene-2-methylhydrazine
• 1-isopropylidene-2-hydroxyethylhydrazine
• 1-isopropylidene-2-formylhydrazine

Acetone′s luminesence intensity is dependent upon the solution components . The absorption of UV light by acetone, results in its photolysis and the production of radials .

Packaging

18 L in VerSA-Flow™

2×10 L in Nowpak™

20 L in Nowpak™

20 L in Pure-Pac™ 2

4, 4×4 L in PVC-coated bottle

50 L in composite drum

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Target organs 
Central nervous system
Supplemental Hazard Statements 
EUH066
RIDADR 
UN1090 - class 3 - PG 2 - Acetone
WGK Germany 
WGK 1
RTECS 
AL3150000
Flash Point(F) 
1.4 °F - closed cup
Flash Point(C) 
-17.0 °C - closed cup

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Pressure-Temperature Calculator for Solvents

*Calculations provide estimated results based on Antoine's Coefficients and their associated temperature range values. Antoine's Coefficients were obtained from the National Institute of Standards an...

Peer-Reviewed Papers
15

References

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