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439215 Sigma-Aldrich

Tetrahydrofuran

for HPLC, ≥99.9%, inhibitor-free

Synonym: Butylene oxide, Oxolane, Tetramethylene oxide

  • CAS Number 109-99-9

  • Empirical Formula (Hill Notation) C4H8O

  • Molecular Weight 72.11

  •  Beilstein/REAXYS Number 102391

  •  EC Number 203-726-8

  •  MDL number MFCD00005356

  •  PubChem Substance ID 329756429

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Properties

Related Categories Analytical Reagents, Analytical/Chromatography, Chromatography Reagents & Solvents, HPLC Plus, HPLC Plus Grade Solvents,
Quality Level   100
grade   for HPLC
vapor density   2.5 (vs air)
vapor pressure   114 mmHg ( 15 °C)
  143 mmHg ( 20 °C)
assay   ≥99.9%
autoignition temp.   610 °F
expl. lim.   1.8-11.8 %
impurities   ≤0.015% peroxide (as H2O2)
  <0.02% water
evapn. residue   <0.0005%
refractive index   n20/D 1.407 (lit.)
bp   65-67 °C (lit.)
mp   −108 °C (lit.)
solubility   H2O: soluble
density   0.889 g/mL at 25 °C (lit.)
λ   H2O reference
UV absorption   λ: 212 nm Amax: 1.0
  λ: 250 nm Amax: 0.180
  λ: 300 nm Amax: 0.020
  λ: 350-400 nm Amax: 0.005
SMILES string   C1CCOC1
InChI   1S/C4H8O/c1-2-4-5-3-1/h1-4H2
InChI key   WYURNTSHIVDZCO-UHFFFAOYSA-N

Description

General description

Tetrahydrofuran (THF) is a saturated cyclic ether with a potential use as a biofuel. Its combustion studies have been reported. Reports suggest it is a better promoter than 1,3 dioxolane for CO2-hydrate formation. The effect of THF on the biological systems has been studied.

Application

Tetrahydrofuran may be used as a solvent in the following processes:
• Formation of diacetylinic polymers.
• RAFT polymerization of p-acetoxystyrene.
• Synthesis of di-tert-butyl-Phosphinoferrocene.
It may be used in the following processes:
• As mobile phase solvent in high-performance liquid chromatography.
• As a solvent in the preparation of spin-coated poly(bisphenol A decane ether).
• Formation of butyrolactone (BTL) by green oxidation method.
• As a solvent for lignin depolymerization to isolate phenolic monomer.

Packaging

4×4 L in PVC-coated bottle

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Supplemental Hazard Statements 
May form explosive peroxides.
RIDADR 
UN 2056 3 / PGII
WGK Germany 
1
RTECS 
LU5950000
Flash Point(F) 
1.4 °F
Flash Point(C) 
-17 °C

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Dispensette™ S
Protocols & Articles

Articles

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Peer-Reviewed Papers
15

References

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